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© 2017-IOS Press and the authors. All rights reserved. Extracellular vesicles including exosomes are released by a variety of cell types including neurons and exhibit molecular profiles that reflect normal and disease states. As their content represents a snapshot of the intracellular milieu, they could be exploited as biomarkers of the otherwise inaccessible brain microenvironment. In addition they may contribute to the progression of neurodegenerative disorders by facilitating the spread of misfolded proteins at distant sites or activating immune cells. This review summarizes recent advances in the study of exosomes in Parkinson's disease pathophysiology and their potential as disease biomarkers.

Original publication

DOI

10.3233/JPD-171176

Type

Journal article

Journal

Journal of parkinson's disease

Publication Date

01/01/2017

Volume

7

Pages

569 - 576