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A drug acting at metabotropic glutamate receptors has recently been reported to be an effective antipsychotic, breaking the rule that only dopamine receptor-blocking drugs have this property. The finding complements accumulating evidence that glutamatergic abnormalities are important in the pathophysiology of schizophrenia.

Original publication

DOI

10.1192/bjp.bp.107.045088

Type

Journal article

Journal

Br J Psychiatry

Publication Date

02/2008

Volume

192

Pages

86 - 87

Keywords

Antipsychotic Agents, Benzodiazepines, Humans, Receptors, Metabotropic Glutamate, Schizophrenia