Search results (28)
« Back to PublicationsMutant TDP-43 drives impairments in axonal transport and glycolysis in a mouse stem-cell-derived motor neuron model of amyotrophic lateral sclerosis (ALS)
Carroll E. et al, (2026), Cell Death & Disease, 17
Extracellular vesicles in TDP-43 proteinopathies: pathogenesis and biomarker potential
Dellar ER. et al, (2025), Molecular Neurodegeneration, 20
High-throughput screen of 100 000 small molecules in C9ORF72 ALS neurons identifies spliceosome modulators that mobilize G4C2 repeat RNA into nuclear export and repeat associated non-canonical translation
Luteijn MJ. et al, (2025), Nucleic Acids Research, 53
Proteome Aggregation in Cells Derived from Amyotrophic Lateral Sclerosis Patients for Personalized Drug Evaluation
Pérez de la Lastra Aranda C. et al, (2024), ACS Chemical Neuroscience, 15, 3945 - 3953
Dynactin-1 mediates rescue of impaired axonal transport due to reduced mitochondrial bioenergetics in amyotrophic lateral sclerosis motor neurons
Dafinca R. et al, (2024), Brain Communications, 6
Cellular and axonal transport phenotypes due to the C9ORF72 HRE in iPSC motor and sensory neurons
Scaber J. et al, (2024), Stem Cell Reports, 19, 957 - 972
Mutant GGGGCC RNA prevents YY1 from binding to Fuzzy promoter which stimulates Wnt/β-catenin pathway in C9ALS/FTD.
Chen ZS. et al, (2023), Nat Commun, 14
C9orf72-ALS human iPSC microglia are pro-inflammatory and toxic to co-cultured motor neurons via MMP9
Vahsen BF. et al, (2023), Nature Communications, 14
Poly(ADP-ribose) promotes toxicity of C9ORF72 arginine-rich dipeptide repeat proteins.
Gao J. et al, (2022), Sci Transl Med, 14
Human iPSC co-culture model to investigate the interaction between microglia and motor neurons
Vahsen BF. et al, (2022), Scientific Reports, 12
Human stem cell models of neurodegeneration: From basic science of amyotrophic lateral sclerosis to clinical translation
Giacomelli E. et al, (2022), Cell Stem Cell, 29, 11 - 35
Axonal TDP-43 condensates drive neuromuscular junction disruption through inhibition of local synthesis of nuclear encoded mitochondrial proteins.
Altman T. et al, (2021), Nat Commun, 12
The Role of Mitochondrial Dysfunction and ER Stress in TDP-43 and C9ORF72 ALS
Dafinca R. et al, (2021), Frontiers in Cellular Neuroscience, 15
An ALS-linked mutation in TDP-43 disrupts normal protein interactions in the motor neuron response to oxidative stress
Feneberg E. et al, (2020), Neurobiology of Disease, 144, 105050 - 105050