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Postdoctoral Researcher

Postdoctoral Researcher

Andrew Castle

Research Summary

My main research interest is the cellular and molecular mechanisms that underpin neurodegeneration. My previous research focused on prion protein – a key player in the group of dementias known as prion diseases. Here, at the University of Oxford, I study alpha-synuclein, which is associated with Parkinson’s disease and other, rarer neurodegenerative disorders. I am using CRISPR screens to identify proteins that modulate the intracellular trafficking and degradation of alpha-synuclein, which will be validated using a variety of biochemical techniques. The long-term goal of this research is to identify proteins that could be targeted therapeutically to reduce the build-up of toxic alpha-synuclein aggregates in patients.  

Recent publications

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