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We use brain imaging techniques to investigate the human visual system, both in its normal state and in disease and disorder.

Vision group
Visual area LOC responds to the generation of words in anophthalmic subjects (born without eyes)

The vision group at FMRIB uses magnetic resonance imaging (MRI) to look at the structure, function and connectivity of the human visual system. We are interested in the functioning of the visual system in its ‘normal’ state in sighted individuals, the changes that occur in people who have disorders of the visual system such as visual impairment or binocular dysfunction and the effects of damage or disease. In addition to structural and functional MRI scanning, members of the vision group use diffusion-weighted imaging to investigate connectivity patterns within the brain and behavioural testing to determine any changes or differences in visual function.

One aspect of our research involves investigating how the brain determines the function of a specific region of the brain. In the case of blind subjects who are anophthalmic, in whom the eyes never developed, we are interested in how the visual pathway is recruited by other neural functions (Gaelle Coullon). For those who lose visual function later in life, through trauma or a stroke (hemianopia), we have several projects designed to understand the residual function and any re-organisation that occurs to minimise visual deficits (Rebecca Millington, Dr Sara Ajina, Ms Stephanie Larcombe). Recently, in collaboration with Prof. Concetta Morrone and Dr Claudia Lunghi in Pisa, we have started to look at the neurochemical basis of short term visual plasticity in adults using magnetic resonance spectroscopy (MRS). 

Dr Betina Ip is investigating how the neurochemistry of the early visual areas interacts with binocular vision. Dr Ivan Alvarez is applying population receptive field (pRF) approaches to multiple areas of neural processing, including contrasting pRFs quantified in different domains, such as motion and depth. 

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