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Professor Colin Espie is the Director, and Dr. Simon Kyle the Deputy Director, of the Experimental and Clinical Sleep Medicine group with the Sleep and Circadian Neuroscience Institute, University of Oxford. We conduct human experimental and clinical studies on sleep and disorders of sleep with the aim of understanding their pathophysiology and in the mechanisms of action of treatments. Our research is supported by numerous national and international funders, including the Wellcome Trust, NIHR, Swiss National Science Foundation, Education Endowment Fund, and the Dr. Mortimer and Theresa Sackler Foundation, amongst others.

Group of sleep researchers on steps of Dunn School of Pathology


We are interested in investigating the predispositional, precipitating and perpetuating factors contributing to sleep disorders, as well as understanding the efficacy and mechanisms of action of cognitive behavioural interventions. We see sleep as a transdiagnostic process, across the lifespan, and so regard sleep health and sleep improvement as a central mediator of physical, emotional and cognitive wellbeing. 

Experimental & Clinical Sleep Medicine is a cross-cutting theme which focuses particularly on two of the strategic aims of the Sleep and Circadian Neuroscience Institute (SCNi).

  1. To apply the knowledge gained from our empirical research to deliver evidence-based and condition specific therapeutics to address sleep and circadian rhythm disruption.
  2. To transfer this knowledge to the broader academic, clinical, public and patient communities using multiple channels of engagement.



Take part in our research. 

Current and past research projects:.

TEEN Sleep

Sleep and Mental Illness

Human Phenotyping

Therapeutic Intervention

Mechanisms of Sleep Restriction Therapy

Efficacy of CBTI on Cognitive Outcomes

Sleep deprivation and emotional processing


The Wellcome Trust 

Sleep and Circadian Neuroscience Institute

Education Endowment Foundation

Dr Mortimer & Theresa Sackler Foundation



John Fell Fund

Innovate UK

Big Health


Selected publications