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We explore the neuropathology of multiple sclerosis and other inflammatory and neurodegenerative diseases using a multidisciplinary team approach to post-mortem brain and spinal cord tissue. The aim is that the understanding derived from these studies will translate into ideas for improved treatments for living patients.

Research strategies of our group. In the Comparative Neuropathology quadrant, we represent the different manifestations of neurodegenerative and inflammatory disease in which we are interested. In the Genetics-Pathology quadrant, we represent our interest in exploring the relationship between genes and pathologic features in post-mortem tissue. In the Transcriptomics/Proteomics-Pathology quadrant, we illustrate some current work linking multiple sclerosis pathology and its relationship to gene expression and protein alterations. In the MRI-Pathology quadrant, we illustrate axonal loss and alterations in the MRI signal of the spinal cord in multiple sclerosis. For each of these strategies, we apply rigorous quantitative neuropathological outcome measures.
Research strategies of our group. In the Comparative Neuropathology quadrant, we represent the different manifestations of neurodegenerative and inflammatory disease in which we are interested. In the Genetics-Pathology quadrant, we represent our interest in exploring the relationship between genes and pathologic features in post-mortem tissue. In the Transcriptomics/Proteomics-Pathology quadrant, we illustrate some current work linking multiple sclerosis pathology and its relationship to gene expression and protein alterations. In the MRI-Pathology quadrant, we illustrate axonal loss and alterations in the MRI signal of the spinal cord in multiple sclerosis. For each of these strategies, we apply rigorous quantitative neuropathological outcome measures.

We work closely with colleagues at the Wellcome Trust Centre for Human Genetics, Department of Physiology, Anatomy, and Genetics, FMRIB, and Immunology at Oxford, as well as the UK MS Tissue Bank at Imperial College, London, the MRI groups at the University of British Columbia and University College London, and Genetics and Genomics Sciences at Mount Sinai, New York.

Research Projects

  • Comparative Neuropathology with Cerebrovascular and Degenerative Diseases
  • Genetic-Pathology Correlations
  • Transcriptomic/Proteomic-Pathology Correlations
  • MRI-Pathology Correlations

FUNDERS

GMSI logo

Medical Research Council Logo

Oxford BRC

Selected publications

nterior optic pathway pathology in CNS demyelinating diseases

Conference paper

Pisa M. et al, (2022), Brain, 145, 4308 - 4319

Cognitive decline and diabetes: a systematic review of the neuropathological correlates accounting for cognition at death

Journal article

Hadley G. et al, (2022), Journal of Neurology, Neurosurgery & Psychiatry, 93, 246 - 253

Vascular disease and multiple sclerosis: a post-mortem study exploring their relationships

Journal article

Geraldes R. et al, (2020), Brain, 143, 2998 - 3012

Invited Review: From nose to gut – the role of the microbiome in neurological disease

Journal article

Bell JS. et al, (2019), Neuropathology and Applied Neurobiology, 45, 195 - 215

Vascular pathology in multiple sclerosis: reframing pathogenesis around the blood-brain barrier

Journal article

Spencer JI. et al, (2018), Journal of Neurology, Neurosurgery & Psychiatry, 89, 42 - 52

Neurite dispersion: a new marker of multiple sclerosis spinal cord pathology?

Journal article

Grussu F. et al, (2017), Annals of Clinical and Translational Neurology, 4, 663 - 679

Fibrin(ogen) and neurodegeneration in the progressive multiple sclerosis cortex

Journal article

Yates RL. et al, (2017), Annals of Neurology, 82, 259 - 270

Back on the scent: the olfactory system in CNS demyelinating diseases

Journal article

Joseph A. and DeLuca GC., (2016), Journal of Neurology, Neurosurgery & Psychiatry, 87, 1146 - 1154

The influence of HLA‐DRB1*15 on motor cortical pathology in multiple sclerosis

Journal article

Yates RL. et al, (2015), Neuropathology and Applied Neurobiology, 41, 371 - 384

Cognitive Impairment in Multiple Sclerosis: Clinical, Radiologic and Pathologic Insights

Journal article

DeLuca GC. et al, (2015), Brain Pathology, 25, 79 - 98

Olfactory Pathology in Central Nervous System Demyelinating Diseases

Journal article

DeLuca GC. et al, (2015), BRAIN PATHOLOGY, 25, 543 - 551

Casting light on multiple sclerosis heterogeneity: the role of HLA-DRB1 on spinal cord pathology

Journal article

DeLuca GC. et al, (2013), Brain, 136, 1025 - 1034

xonal and oligodendrocyte-localized IgM and IgG deposits in MS lesions

Journal article

Sádaba MC. et al, (2012), Journal of Neuroimmunology, 247, 86 - 94

Diffusion imaging of whole, post-mortem human brains on a clinical MRI scanner

Journal article

Miller KL. et al, (2011), NeuroImage, 57, 167 - 181

Spinal Cord Neuronal Pathology in Multiple Sclerosis

Journal article

Gilmore CP. et al, (2009), Brain Pathology, 19, 642 - 649

n extremes of outcome strategy provides evidence that multiple sclerosis severity is determined by alleles at the HLA-DRB1 locus

Journal article

DeLuca GC. et al, (2007), Proceedings of the National Academy of Sciences, 104, 20896 - 20901

The role of hereditary spastic paraplegia related genes in multiple sclerosis

Journal article

DeLuca GC. et al, (2007), Journal of Neurology, 254, 1221 - 1226

The contribution of demyelination to axonal loss in multiple sclerosis

Journal article

DeLuca GC., (2006), Brain, 129, 1507 - 1516

The extent of axonal loss in the long tracts in hereditary spastic paraplegia

Journal article

DeLuca GC. et al, (2004), Neuropathology and Applied Neurobiology, 30, 576 - 584

Related research themes