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The Clinical Ophthalmology Research Group is led by Professor Robert MacLaren. Over the last decade, Professor MacLaren has been at the forefront of translational medical research into novel clinical treatments for incurable retinal diseases, and is regarded internationally as a leader in the fields of retinal gene therapy, electronic retinas and ocular robotic surgery.

Professor Robert MacLaren and team in surgery

The main objectives of Professor MacLaren’s translational medical research programme are the:

  • Development of novel genetic, cellular and molecular therapies for retinal diseases.
  • Investigation of innovative retinal prosthetics and ocular surgical techniques.
  • Testing of novel therapies for retinal diseases in human clinical trials.

Donations to Professor MacLaren’s DPhil research grant support will provide valuable assistance in supporting the innovative research undertaken to develop novel treatments for retinal diseases.

Selected publications

Initial results from a first-in-human gene therapy trial on X-linked retinitis pigmentosa caused by mutations in RPGR

Journal article

Cehajic-Kapetanovic J. et al, (2020), Nature Medicine, 26, 354 - 359

Beneficial effects on vision in patients undergoing retinal gene therapy for choroideremia

Journal article

Xue K. et al, (2018), Nature Medicine, 24, 1507 - 1512

First-in-human study of the safety and viability of intraocular robotic surgery

Journal article

Edwards TL. et al, (2018), Nature Biomedical Engineering, 2, 649 - 656

Visual Acuity after Retinal Gene Therapy for Choroideremia

Journal article

Edwards TL. et al, (2016), New England Journal of Medicine, 374, 1996 - 1998

Retinal gene therapy in patients with choroideremia: initial findings from a phase 1/2 clinical trial

Journal article

MacLaren RE. et al, (2014), The Lancet, 383, 1129 - 1137