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Prevention of hypertensive injury to the brain by intensive treatment in intracerebral haemorrhage

A pilot randomised trial of home telemetry-guided treatment 

currently  RECRUITing participants -  61 randomised as of 15/10/2021 (8 UCL, 3 IMPERIAL, 5 ST GEORGES , 6 OXFORD, 3 glasgow, 1 salford, 3 Sheffield, 8 kings, 8 Edinburgh, 4 nottingham, 11 Addenbrookes, 1 lUTON AND dUNSTABLE)

The trial will show whether intensive lowering of blood pressure (BP) using telemetric home monitoring in survivors of intracerebral haemorrhage (ICH) is feasible, safe and effective in reducing brain injury. If successful this study will be a precursor for a larger definitive trial. Our intervention should allow survivors of ICH to know, understand, and manage their own BP to prevent strokes and cognitive impairment, and improve outcomes.

PROHIBIT-ICH will randomise participants to compare a strategy of intensive BP treatment (target <120/80 mm Hg) guided by telemetric home monitoring, versus standard primary care (current RCP guideline is 130/80 mm Hg), in 112 adult survivors of hypertension-related ICH. We will establish the feasibility and safety of the intervention, the efficacy of BP reduction, and explore whether it reduces the progression of small vessel disease (SVD) related injury on brain MRI.