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Ucl stroke research centre

Prevention of hypertensive injury to the brain by intensive treatment in intracerebral haemorrhage

currently  RECRUITing participants -  16 randomised (4 UCL, 2 IMPERIAL, 2 ST GEORGES , 1 OXFORD, 1 glasgow, 1 salford, 1 Sheffield, 2 kings, 1 Edinburgh, 1 nottingham)

The trial will show whether intensive lowering of blood pressure (BP) using telemetric home monitoring in survivors of intracerebral haemorrhage (ICH) is feasible, safe and effective in reducing brain injury. If successful this study will be a precursor for a larger definitive trial. Our intervention should allow survivors of ICH to know, understand, and manage their own BP to prevent strokes and cognitive impairment, and improve outcomes.

PROHIBIT-ICH will randomise participants to compare a strategy of intensive BP treatment (target <120/80 mm Hg) guided by telemetric home monitoring, versus standard primary care (current RCP guideline is 130/80 mm Hg), in 112 adult survivors of hypertension-related ICH. We will establish the feasibility and safety of the intervention, the efficacy of BP reduction, and explore whether it reduces the progression of small vessel disease (SVD) related injury on brain MRI.

An example of bluetooth blood pressure reporting An example of bluetooth blood pressure reporting