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Kevin Talbot


Kevin Talbot qualified in medicine (MB BS) with Distinction from the University of London and trained in Neurology in London and Oxford. He joined the laboratory of Professor Kay Davies in 1995 to work on the childhood motor neuron disorder spinal muscular atrophy, which has remained a major focus of his research ever since. From 1998-2001 he was Clinical Lecturer in Neurology and from 2001-2006 held an MRC Clinician Scientist Fellowship. He leads a multidisciplinary team providing a clinical service for patients with motor neuron disease from all over the South of England. In 2010 he became Professor of Motor Neuron Biology

Awards, Training and Qualifications

  • MB BS  University of London 1990
  • DPhil  University of Oxford 1998
  • FRCP  Royal College of Physicians, London 2006

Kevin Talbot


Head of Department and Professor of Motor Neuron Biology

Research Summary

The main aim of my research is to identify targets for therapy in motor neuron diseases such as amyotrophic lateral sclerosis (ALS). In particular, we use laboratory models including motor neurons from induced pluripotent stem cells from patients to understand why motor neuron integrity fails in the presence of certain genetic mutations (eg; TDP-43 or C9orf72 in ALS). We also use these models to identify drug targets. Our work takes place in the context of a larger team of researchers in Oxford interested in translational research in neurodegenerative diseases, and we have many national and international collaborations. We are active members of the UK MND Research Institute.


Professor Talbot is not currently accepting new DPhil students.

Sources of Funding