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Our group works on vision restoration by interventional genetics and robotics. We focus on developing therapies for inherited retinal degenerations, the leading cause of blindness in the working population, as well as therapies for more common forms of blindness, the age related macular degeneration (AMD), retinal vein occlusions and glaucoma.

Kapetanovic Lab

Our research focuses on vision restoration by interventional genetics and robotics. We work on developing therapies for inherited retinal degenerations, the leading cause of blindness in the working population, as well as therapies for more common forms of blindness, the age related macular degeneration (AMD), retinal vein occlusions and glaucoma. 

MacLaren Group Annual Dinner 2024

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Selected publications

Bioengineering strategies for restoring vision.

Journal article

Cehajic-Kapetanovic J. et al, (2023), Nat Biomed Eng, 7, 387 - 404

Changes in Retinal Sensitivity Associated With Cotoretigene Toliparvovec in X-Linked Retinitis Pigmentosa With RPGR Gene Variations

Journal article

von Krusenstiern L. et al, (2023), JAMA Ophthalmology, 141, 275 - 275

Impaired glutamylation of RPGR ORF15 underlies the cone-dominated phenotype associated with truncating distal ORF15 variants

Journal article

Cehajic-Kapetanovic J. et al, (2022), Proceedings of the National Academy of Sciences, 119

First-in-Human Robot-Assisted Subretinal Drug Delivery Under Local Anesthesia.

Journal article

Cehajic-Kapetanovic J. et al, (2022), Am J Ophthalmol, 237, 104 - 113

Genome-Editing Strategies for Treating Human Retinal Degenerations

Journal article

Quinn J. et al, (2021), Human Gene Therapy, 32, 247 - 259

Optogenetic Gene Therapy for the Degenerate Retina: Recent Advances

Journal article

McClements ME. et al, (2020), Frontiers in Neuroscience, 14

Highest reported visual acuity after electronic retinal implantation

Journal article

Cehajic Kapetanovic J. et al, (2020), Acta Ophthalmologica, 98, 736 - 740

Initial results from a first-in-human gene therapy trial on X-linked retinitis pigmentosa caused by mutations in RPGR

Journal article

Cehajic-Kapetanovic J. et al, (2020), Nature Medicine, 26, 354 - 359

Efficacy and Safety of Glycosidic Enzymes for Improved Gene Delivery to the Retina following Intravitreal Injection in Mice

Journal article

Cehajic-Kapetanovic J. et al, (2018), Molecular Therapy - Methods & Clinical Development, 9, 192 - 202

Restoration of Vision with Ectopic Expression of Human Rod Opsin

Journal article

Cehajic-Kapetanovic J. et al, (2015), Current Biology, 25, 2111 - 2122