Research groups
Dr Sophie Binks
Clinical Lecturer
Honorary Neurology SpR
Brief biography
After a career in medical communications, I retrained in medicine and graduated with distinction and first in my cohort from Brighton & Sussex Medical School in 2013 (Professor Alasdair Smith prize for best performance in the overall programme), being awarded 18 prizes/scholarships during my medical degree, including three-times recipient of the Dean’s prize for best overall performance (years 1, 2 & 4). I completed a fellowship in autoimmune neurology in Oxford in 2016-2017 and was awarded my DPhil in neuroimmunology from the University of Oxford in 2022. In my current role, I work as a clinician-scientist and early career researcher at NDCN and the John Radcliffe Hospital, Oxford. My research programme focuses on clinical and genetic aspects of autoimmune encephalitis (AE). Significant breakthroughs I have published include human leucocyte antigen genetics (2018) and additional genetic risk loci (2025) in AE associated with antibodies to leucine-rich glioma-inactivated 1 (LGI1-Ab-E) and contactin-associated protein 2 (CASPR2). I have also been at the forefront of describing the impact of fatigue and quality of life outcomes in LGI1-Ab-E (2021 and 2024), and a unique naturally-occurring animal model of LGI1-Ab-E in pet cats (2025). As a thought leader in this field, I am active as an international speaker and educator, including supervision of postgraduate students, patient engagement activities, and professional leadership roles.
Key publications
Novel risk loci in LGI1-antibody encephalitis: genome-wide association study discovery and validation cohorts
Journal article
Binks SNM. et al, (2025), Brain, 148, 737 - 745
Residual Fatigue and Cognitive Deficits in Patients After Leucine-Rich Glioma-Inactivated 1 Antibody Encephalitis
Journal article
Binks SNM. et al, (2021), JAMA Neurology, 78, 617 - 617
Distinct HLA associations of LGI1 and CASPR2-antibody diseases
Journal article
Binks S. et al, (2018), Brain, 141, 2263 - 2271
LGI1, CASPR2 and related antibodies: a molecular evolution of the phenotypes
Journal article
Binks SNM. et al, (2018), Journal of Neurology, Neurosurgery & Psychiatry, 89, 526 - 534
Effect of high-dose simvastatin on cognitive, neuropsychiatric, and health-related quality-of-life measures in secondary progressive multiple sclerosis: secondary analyses from the MS-STAT randomised, placebo-controlled trial.
Journal article
Chan D. et al, (2017), Lancet Neurol, 16, 591 - 600
Recent publications
Feline hippocampal necrosis and temporal lobe epilepsy: A review of current literature and definitions.
Journal article
Hall RV. et al, (2026), Vet J, 317
The gut microbiome associated with LGI1 ‐antibody encephalitis
Journal article
Gilbert E. et al, (2025), Epilepsia, 66, 4411 - 4424
Distinctive seizure signature in the first video case-control study of a naturally-occurring feline autoimmune encephalitis model
Journal article
Binks SNM. et al, (2025), Brain, Behavior, and Immunity, 126, 289 - 296
Capturing what matters: Patient‐reported LGI1‐ANTibody encephalitis outcome RatiNg scale (LANTERN)
Journal article
Kelly MJ. et al, (2025), Annals of Clinical and Translational Neurology, 12, 821 - 831