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  • Kevin Talbot
    Kevin Talbot

    Head of Department and Professor of Motor Neuron Biology

Emily Carroll

BSc (Hons), MSc (Oxon)

DPhil Student

Investigating mechanisms of TDP-43 toxicity in mouse embryonic stem cell (mESC)-derived motor neurons

My DPhil research focusses on investigating the role of mutant TDP-43 in the pathophysiology of amyotrophic lateral sclerosis. In mESC-derived motor neurons, I am studying the effects of the TARDBP M337V mutation on cellular phenotypes including mitochondrial function, cellular energy metabolism and axonal transport. This work is funded by the Oxford-MRC Doctoral Training Partnership.