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Contact information

Email
emily.carroll@ndcn.ox.ac.uk

Colleges

Magdalen College

Collaborators

Kevin Talbot

Head of Department and Professor of Motor Neuron Biology

Emily Carroll

BSc (Hons), MSc (Oxon), DPhil

Post-doctoral Researcher

Investigating mechanisms of TDP-43 toxicity in mouse embryonic stem cell (mESC)-derived motor neurons

My research focusses on investigating the role of mutant TDP-43 in the pathophysiology of amyotrophic lateral sclerosis. In mESC-derived motor neurons, I am studying the effects of the TARDBP M337V mutation on cellular phenotypes including stress responses, cellular energy metabolism and axonal transport. I am also using this model as a platform for drug discovery, to identify compounds that reverse pathological phenotypes associated with the expression of mutant TDP-43.

Recent publications

Mutant TDP-43 drives impairments in axonal transport and glycolysis in a mouse stem-cell-derived motor neuron model of amyotrophic lateral sclerosis (ALS)

Carroll E. et al, (2026), Cell Death & Disease, 17

Recent developments in gene therapy for Parkinson’s disease

Szunyogh S. et al, (2025), Molecular Therapy, 33, 2052 - 2064

Drug repurposing in amyotrophic lateral sclerosis (ALS)

Carroll E. et al, (2025), Expert Opinion on Drug Discovery, 20, 447 - 464

Dynactin-1 mediates rescue of impaired axonal transport due to reduced mitochondrial bioenergetics in amyotrophic lateral sclerosis motor neurons

Dafinca R. et al, (2024), Brain Communications, 6

C9orf72-ALS human iPSC microglia are pro-inflammatory and toxic to co-cultured motor neurons via MMP9

Vahsen BF. et al, (2023), Nature Communications, 14

More publications