BM DPhil FRCA
Senior Clinical Research Fellow
- Consultant Anaesthetist and Associate Professor
FMRI of respiratory control
Disorders of respiratory control are implicated in a wide spectrum of disease including: chronic obstructive airways disease, asthma, neurodegenerative diseases, sleep apnoea and sudden infant death syndrome. In particular, chronic obstructive airways disease causes distressing shortness of breath, and is one of the major debilitating diseases in the world. Drugs used for pain relief, such as morphine, have potentially fatal side effects due to their effects upon respiratory centres in the brain. My research centres upon investigating mechanisms of respiratory control, and the processes underlying breathlessness, using non-invasive magnetic resonance imaging techniques.
Imaging brain perfusion changes following aneurysmal subarachnoid haemorrhage
Delayed cerebral ischaemia is a major cause of morbidity and mortality following subarachnoid haemorrhage. Successful targeted treatment requires an accurate, non-invasive, and reproducible measure of cerebral perfusion. Current techniques are limited in their clinical application as they only image larger arteries and require the use of contrast agents and/or ionising radiation. We are trialing novel magnetic resonance imaging techniques that do not require exogenous contrast agents that demonstrate quantitative measures of cerebral perfusion at the tissue level. This would potentially facilitate the early and targeted use of vasospasm therapies and so reduce long-term morbidity and mortality.
Breathlessness and the body: Neuroimaging clues for the inferential leap
Faull OK. et al, (2017), Cortex, 95, 211 - 221
Treating breathlessness via the brain: changes in brain activity over a course of pulmonary rehabilitation.
Herigstad M. et al, (2017), Eur Respir J, 50
Opioid suppression of conditioned anticipatory brain responses to breathlessness.
Hayen A. et al, (2017), Neuroimage, 150, 383 - 394
The cortical connectivity of the periaqueductal gray and the conditioned response to the threat of breathlessness
Faull OK. and Pattinson KTS., (2017), eLife, 6
Calcium channel blockade with nimodipine reverses MRI evidence of cerebral oedema following acute hypoxia.
Rowland MJ. et al, (2017), J Cereb Blood Flow Metab