Mapping circuits, modeling motivation, guiding precision interventions, digital phenotyping and biofeedback
The NeuroSCOPE lab investigates the brain circuits underlying motivation and mood, with a particular focus on characterising depression. We are interested in combining multi-modal neuroscientific tools to not only deepen our understanding of the human brain but also to advance personalised mental healthcare. Using high-resolution 7T MRI, reinforcement learning paradigms, and digital phenotyping via EMAware technology, we aim to characterise motivation and its neural mechanisms. Through integrating neuroimaging with precision biofeedback interventions, we aim to map and modulate brain activity, implementing a rigorous and individualised approach to understanding and treating mood disorders.
Our team
Latest publications
Tetraspanin-based immunocapture for high-depth proteomic profiling of extracellular vesicles from cerebrospinal fluid for biomarker discovery
Journal article
Dellar ER. et al, (2026), Clinical Proteomics, 23
Understanding the relationship between post-stroke cognitive impairments and depression: The role of loneliness
Journal article
Overman MJ. et al, (2026), Journal of Affective Disorders, 403, 121305 - 121305
Investigating ethnicity-related variability in the human L-cone spectral sensitivity function
Journal article
Schneider AC. et al, (2026), Vision Research, 243, 108769 - 108769
Key Readings
Digital measures of activity and motivation impact depression and anxiety in the real world
Cross-species dissection of the modular role of the ventral tegmental area in depressive disorders
Ventral tegmental area integrity measured with high-resolution 7-Tesla MRI relates to motivation across depression and anxiety diagnoses