Contact information
Research groups
Colleges
Websites
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College Teaching
The Queen's College
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Research Affiliate
Karolinska Institutet
David Menassa
Academic Visitor
MA, MPhil, DPhil, PGCert, FHEA
Research
I am an academic visitor to the Department of Neuropathology attached to the Parkinson’s Neuropathology group and research affiliate of the paediatric neuro-oncology group at the Karolinska Institutet. My research is focused on translational human neuropathology in neurodegenerative and neurodevelopmental disease. Importantly, I am interested in how microglia, the brain’s resident macrophages, participate in mechanisms of health, injury, and repair. I use neuroanatomical, neuropathological and computational methods including machine learning and spatial transcriptomics to investigate the molecular signature of disease. I collaborate with various groups in the UK and abroad including the Blomgren lab (Karolinska), the Holcman lab (Ecole Normale Supérieure), the Lagache lab (Pasteur), the Long lab (KCL), the Vernon lab (KCL), the Krsnik lab (Zagreb), the Tremblay lab (Victoria), the Sierra lab (Achucarro) & the Heneka lab (Luxembourg).
Teaching
I have formal pedagogic training (PGCert) and I am a Fellow of the Higher Education Academy (FHEA). I teach the neuroscience syllabus to second-year undergraduates reading medicine and first-year undergraduates reading biomedical science. I also provide tutorials for visiting students in research design and analysis, statistics, comparative physiology, and neurobiology. I supervise FHS medical students who take an interest in submitting extended essays on microglia, neuroimmunology, neurodevelopmental disorders, and neurodegenerative disease as part of the FHS medical sciences’ examination. I occasionally lecture on the MSc in clinical neuropsychiatry course at King's College London.
Education
I obtained my BSc in biological and earth sciences at the Université Saint Joseph in Beirut in 2006. Following a brief spell at the École Normale Supérieure in Paris, I completed my MSc in applied physiology at the University of Oxford followed by an MPhil in bioenergetics at the University of Cambridge. In 2009, I was awarded a Clarendon scholarship to pursue my DPhil studies in clinical neurology at the University of Oxford. Since 2014, I have held various postdoctoral appointments at Bristol, Oxford, Southampton and Oslo. I joined the Queen’s college at the University of Oxford in 2017 as lecturer of neuroscience.
Funding
National Institutes of Health
The British Council & the Alliance Française
Key publications
Unraveling microglial spatial organization in the developing human brain with DeepCellMap, a deep learning approach coupled with spatial statistics
Journal article
Perochon T. et al, (2025), Nature Communications, 16
Microglial contribution to the pathology of neurodevelopmental disorders in humans
Journal article
Matuleviciute R. et al, (2023), Acta Neuropathologica, 146, 663 - 683
Microglial Characterization in Transient Human Neurodevelopmental Structures
Journal article
Menassa DA. et al, (2023), Developmental Neuroscience, 45, 1 - 7
The spatiotemporal dynamics of microglia across the human lifespan
Journal article
Menassa DA. et al, (2022), Developmental Cell, 57, 2127 - 2139.e6
ism Spectrum Disorders: Multiple Routes to, and Multiple Consequences of, Abnormal Synaptic Function and Connectivity
Journal article
Carroll L. et al, (2021), The Neuroscientist, 27, 10 - 29
Microglial Dynamics During Human Brain Development
Journal article
Menassa DA. and Gomez-Nicola D., (2018), Frontiers in Immunology, 9
Recent publications
Epigenetic control of microglial developmental milestones from proliferative progenitors to efficient phagocytes.
Preprint
Sierra A. et al, (2026)
Selective blockade of microRNA-31-5p/calcitonin receptor interaction reverses established atrial fibrosis and atrial arrhythmia substrate
Journal article
Trompf* J. et al, (2026)
WEAKLY SUPERVISED SEGMENTATION AND CLASSIFICATION OF ALPHA-SYNUCLEIN AGGREGATES IN BRIGHTFIELD MIDBRAIN IMAGES.
Preprint
Dereure E. et al, (2025)
The postdoc paradox: a career without a path.
Journal article
Pansieri J. et al, (2025), Brain, 148, 4175 - 4179