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Division of Clinical Neurology

We are committed to the development of research that improves understanding of the nervous system in health and disease. We are responsible for teaching clinical neurology to medical students and trainee neurologists.

Academic Neuropathology Unit

Academic Neuropathology Unit

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MRC Brain Network Dynamics Unit

MRC Brain Network Dynamics Unit

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Public discover how we are tackling brain diseases

Public discover how we are tackling brain diseases

Read more

What's new

New consortium to investigate aggregated proteins in Alzheimer’s and Parkinson’s diseases

10 April 2017

Research Clinical Neurology
New partnership with Muscular Dystrophy UK

28 March 2017

Funding Award Clinical Neurology
Multiple Sclerosis Patient Day

24 March 2017

Clinical Neurology

NDCN publications

Subthalamic nucleus beta and gamma activity is modulated depending on the level of imagined grip force.
Fischer P. et al, (2017), Exp Neurol, 293, 53 - 61
Moderate alcohol consumption as a risk factor for adverse brain outcomes and cognitive decline: longitudinal cohort study
Topiwala A. et al, (2017), British Medical Journal
A preliminary investigation of sleep quality in functional neurological disorders: Poor sleep appears common, and is associated with functional impairment
Graham CD. and Kyle SD., (2017), Journal of the Neurological Sciences, 378, 163 - 166

More publications

Tackling Brain Diseases

Head

Kevin Talbot

Head of Clinical Neurology and Professor of Motor Neuron Biology

kevin.talbot@ndcn.ox.ac.uk

Contact

t: 01865 234829 e: enquiries@ndcn.ox.ac.uk

How to find us

Research Groups

We employ mathematical models to understand the computations performed by the neural circuits during action selection, and the pathological patterns of activity emerging there in Parkinson’s disease.

Action Selection Modelling Group

We want to understand how - and why - brain function can be disturbed to lead to inattention, poor memory and abnormal decision making. Our aim is to develop new treatments for these conditions across a range of neurological disorders.

Cognitive Neurology Research Group

We provide a nationally commissioned specialised service for the diagnosis and management of children and adults in whom a congenital myasthenic syndrome is suspected.

Congenital Myasthenia Service

Neuromyelitis optica (NMO) is a rare disease causing inflammation in the spinal cord and optic nerves. The NMO service brings together expertise in diagnostics and clinical management to improve outcomes for this often isolated group of patients.

Diagnostic and Advisory Service for Neuromyelitis Optica

Our goal is to define how activity in large populations of neurons is coordinated in healthy movement and how such coordination may go awry in diseases, translating this information in to improved treatment for Parkinson’s Disease and other disorders of movement.

Experimental Neurology

Our research aims to understand the characteristics of individual brain tumours, combining cutting edge brain imaging, molecular neuropathology and neurosurgical techniques to develop personalized approaches for first-line cancer surgery.

Glioma Neurosurgery Research Group

CPSD runs several research studies looking into the causes, investigation, and management of large artery atherosclerosis, carotid stenosis, vertebral artery disease and intracranial atherosclerosis.

Large Artery Disease

Memory Research Group

Memory Research Group

Our aim is to understand fundamental biological processes that could inform the development of targeted therapies and innovative biomarkers in neurodegenerative and neurogenetic disorders.

Molecular Neurodegeneration Research Group

Our group investigates the role of risk factors in the development of multiple sclerosis through functional genetic and neuro-immunological analyses, with the aim of translating these findings into a clinical utility.

Multiple Sclerosis Basic and Translational Research Group

Our group aims to deliver the highest quality translational and clinical research within both investigator- and commercial-led clinical trials with a focus on relieving the disease burden of MS to patients and their carers.

Multiple Sclerosis Clinical Trials Unit

Our aim is to gain a better understanding of the response of the peripheral nervous system to injury in order to develop strategies to promote peripheral nerve repair and to prevent the development of neuropathic pain. To do this we employ a variety of multi-disciplinary techniques ranging from transgenic models to human psychophysical studies and genetics.

Neural Injury Group

This cross-disciplinary research group links neuropathology, endocrinology and molecular genetics to explore how the genetics and epigenetics of pituitary tumours influences clinical characteristics and to identify targets for therapeutic intervention.

Neuro-Endocrinology Research Group

Our projects study cognitive/psychiatric disorders and comparative evolutionary neuroscience. We are interested in the relationship between brain structure and function in disease, development and aging - particularly related to language and social cognition.

Neuroanatomy and Cognition Group

We explore the neuropathology of multiple sclerosis and other inflammatory and neurodegenerative diseases using a multidisciplinary team approach to post-mortem brain and spinal cord tissue. The aim is that the understanding derived from these studies will translate into ideas for improved treatments for living patients.

Neurodegeneration and Inflammation Research Group

Our aim is to elucidate the pathophysiological basis of human neurological disorders from genetic molecular networks to complex neural systems. We achieve this through development of relevant disease models that will then serve as novel and robust platforms for drug discovery.

Neurogenetic Disorders Group

Our group aims to characterise the immune system in patients with autoantibody-mediated diseases of the nervous system to better diagnose and understand the underlying disease processes, and provide a rational approach to immunotherapies.

Autoimmune Neurology Group

Our objective is to develop ways of accurately measuring neurological disorders such as Parkinson's disease.

NeuroMetrology Lab

We work to translate an understanding of the molecular mechanisms of disease at the neuromuscular synapse into treatments. Our work led us to be commissioned to provide a National Advisory and Diagnostic Service for congenital myasthenic syndromes.

Neuromuscular Disorders

Our research interests include cortical disorders of vision and cognitive neuroscience particularly using eye movements to understand brain function and as biomarkers for neurodegenerative diseases.

OcuLab – Vision, Cognition, Eye Movements and Augmentation

The Oxford Project to Investigate Memory and Ageing (OPTIMA) started in 1988 and the last LEAD participants were seen in March 2015. We are no longer recruiting to any of the cohorts. However, we are currently creating the OPTIMA Legacy Resource from which data collected from the OPTIMA cohorts is available and samples are biobanked and available. Brain tissue is available as part of the Brains For Dementia Research (BDR) collection. Requests for data or samples should go to Professor Wilcock.

OPTIMA

We are a forward-looking dynamic group interested in all aspects of clinical and experimental epileptology with an emphasis on clinically relevant research. The Group draws together all relevant disciplines across Oxford University Hospitals and the University of Oxford.

Oxford Epilepsy Research Group

We aim to provide excellent multidisciplinary clinical care to patients with headache disorders and to pursue cutting edge research to better understand the mechanism of headache and find better treatments

Oxford Headache Centre

Our research is aimed at improving understanding of motor neuron diseases, principally amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA), to find treatments to improve the lives of patients with these currently incurable conditions.

Oxford Motor Neuron Disease Centre

We work to improve the clinical care and access to research for people with Parkinson’s, atypical parkinsonian and movement disorders. Our research has won us numerous awards and recognition in the international community.

Oxford Movement Disorders Group

The Oxford Vascular Study (OxVasc) investigates vascular diseases (e.g. strokes, heart attacks) in patients registered with eight general practices in Oxfordshire. We run a rapid-access clinic for patients with suspected Transient Ischaemic Attacks (TIAs) or minor strokes.

Oxford Vascular Study