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Biography

Michele Hu is Associate Professor in the Department of Clinical Neurology at the Nuffield Department of Clinical Neurosciences, University of Oxford and Consultant Neurologist at Oxford University Hospitals NHS Foundation Trust. After obtaining her medical degree from the University of London in 1993, Michele’s interest in Parkinson’s disease started in earnest in 1998 when she was awarded an Action Research Training Fellowship to study brain function in Parkinson’s disease patients using MRI and PET imaging techniques. In 2001 she was awarded her PhD based on this work, and went on to train in Parkinson’s disease and movement disorders at the National Hospital for Neurology and Neurosurgery, Royal Free Hospital and King’s College Hospital, London.

Since commencing her consultant appointment in 2005, Michele has helped build the clinical Parkinson’s Disease, Atypical Parkinson's and Movement Disorders service at the John Radcliffe Hospital, Oxford University Hospitals NHS Trust. She is currently medical Parkinson's lead for the Trust, leads the Thames Valley Duodopa PD service, and looks after around 600 PD and 100 atypical PD patients (with MSA, PSP and CBD) across the Thames Valley. In 2013 she made the transition from an NHS Consultant Neurologist post to an academic clinician neuroscientist post with Oxford University at the Nuffield Department of Clinical Neurosciences. This post allows her to focus on her primary research interests which include testing and validating pragmatic clinical biomarkers for the accurate diagnosis and prognostication of both prodromal and early motor Parkinson's disease. 

Research Summary

Awards, Training and Qualifications

  • MBBS  University of London 1993
  • PhD  University of London 2001
  • FRCP  Royal College of Physicians, London 2009

Sources of Funding

  • Parkinson's UK Monument Discovery Award to the Oxford Parkinson's Disease Centre (OPDC), 2010-2020 (£10.8 Million total)
  • Oxford Biomedical Research Centre (BRC) Neurological Conditions Theme
  • NIHR Clinical Research Network: Thames Valley and South Midlands
  • Innovative Medicines Initiative. “StemBANCC. Stem cells for Biological Assays of Novel drugs and prediCtive toxicology”
  •  ”Virtual, physiological and computational neuromuscular models for the predictive treatment of Parkinson’s Disease- NoTremor”. EU small or medium-scale focused research project (STREP) Award
  • Oxford/UCB Alliance. "Novel biomarkers to understand the earliest pathological pathways in Parkinson’s disease". 
  • “Biomarkers for Dementia and Cognitive decline in Parkinson’s disease”, Parkinson’s UK innovation grant

  • “Harmonization of biomarker assessment in longitudinal cohort studies in Parkinson’s disease”,  JPND research programme grant: EU Joint Programme- Neurodegenerative Disease Research.

  •  “Development of potential diagnostic biomarkers in Parkinson’s disease”, Michael J. Fox Foundation Biomarker Grant. 

  • “Twinning for a comprehensive clinical centre for  diagnosis and treatment of Parkinson’s disease: CENTRE PD”, Principle Investigator Prof Rejko Kruger, co-I and Oxford Group Lead Michele Hu. H2020-TWINN-2015 EU funding

  • “Dopaminergic correlates of resting state fMRI activity in REM sleep behaviour disorder”, Principal Investigator Michele Hu. GE Healthcare project grant

  • “Prodromal Gait” Principle Investigator Lynn Rochester, Newcastle, co-applicant Michele Hu. NIHR funded project grant

Michele Hu

MBBS FRCP PhD


Associate Professor and Consultant Neurologist

My connections

Research Summary

‘Understanding the early pathological pathways to Parkinson’s disease’, Parkinson’s UK Monument Discovery Award, awarded September 2009 and 2014.PI- Professor Richard Wade-Martins, co-PI Dr Michele Hu.

The Oxford Parkinson’s Disease Centre applied for this £5.0 million Discovery Award among national competition in July 2009, with a successful £5.8 million renewal funding application awarded in 2014.This multi-disciplinary project brings together scientists from Oxford University with international expertise in genomics; the development, analysis and utilisation of animal models using the tools of molecular genetics, neuropathology and neuropharmacology; and the analysis of biomarkers including a proteomics study and novel MRI paradigms in a large clinical cohort of 1500 people with Parkinson’s disease.

Dr Michele Hu leads the clinical theme  in establishing a cohort of early Parkinson’s disease patients recruited from a population base across the Thames Valley, and followed longitudinally over 10 years to develop and validate early PD biomarkers. So far, in excess of 1500 participants in total, who comprise Parkinson's and control subjects, Parkinson's siblings and individuals with REM sleep behaviour disorder, have been recruited to this study. Her current funding facilitates translational research in the field of longitudinal cohort studies and biomarkers of early pre-motor and motor Parkinson’s disease.

Short Description

Highlights from the Oxford Parkinson's Disease Centre 2017

OTHER RESEARCH ACTIVITIES

Dr Michele Hu is currently working with Dr Chrystalina Antoniades and Professor Chris Kennard at the Nuffield Department of Clinical Neurosciences, Oxford University to pilot and develop eye movement saccadometry and hand tapping measurements in early and premotor Parkinson’s patients. She is research director for Parkinson’s disease in the Thames Valley Dementias and Neurodegenerative Disease Research Network (DeNDRoN) and a member of the national DeNDRoN Parkinson’s Clinical Study Group, which aims to promote high quality research in neurodegenerative disorders. She chairs the Research Engagement sub-committee of the UK Parkinson's Excellence Network, formed in 2015 to promote universal standards of excellence of care for Parkinson's individuals.

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Recent Publications

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