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About one billion people worldwide take regular aspirin, usually to prevent heart attacks or strokes. But a new study suggests a more tailored strategy is required.

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The team, led by Peter Rothwell, studied detailed data from their own previous trials (with over 130,000 participants) and showed that standard low-dose aspirin (75-100mg daily) was indeed only effective in preventing heart attacks and strokes in people weighing less than 70kg.

In contrast, higher doses were only effective at weight above 70kg, and were potentially harmful at lower weight. Effects on other outcomes, including cancer, were also dependent on body size.

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Read the Original Lancet Paper