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Oculomotor abnormalities are fast becoming a proxy for disease diagnosis and progression. Saccades-ballistic eye movements-are known to be affected by dopaminergic cell loss in the basal ganglia, caused by Parkinson's disease. Pharmaceutical and neurosurgical interventions such as deep brain stimulation and functional neurosurgery have both been noted to have an effect on saccades. Comparing and contrasting these effects may yield insights into Parkinson's disease pathophysiology, and the mechanisms of pharmacological and neurosurgical treatments. Computational models of saccadic control, such as the LATER model, can help to interpret the distribution of saccadic latencies, providing a framework for objectively comparing the effects of pharmaceutical interventions and deep brain stimulation.

Original publication

DOI

10.1016/bs.pbr.2019.04.020

Type

Chapter

Publication Date

2019

Volume

249

Pages

297 - 305

Keywords

Basal ganglia, Deep brain stimulation, Eye movements, LATER model, Oculomotor, Parkinson's disease, Saccades, Stereotactic neurosurgery, Antiparkinson Agents, Basal Ganglia, Deep Brain Stimulation, Humans, Models, Neurological, Neuronavigation, Ocular Motility Disorders, Parkinson Disease, Saccades