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Studies on human monetary prediction and decision making emphasize the role of the striatum in encoding prediction errors for financial reward. However, less is known about how the brain encodes financial loss. Using Pavlovian conditioning of visual cues to outcomes that simultaneously incorporate the chance of financial reward and loss, we show that striatal activation reflects positively signed prediction errors for both. Furthermore, we show functional segregation within the striatum, with more anterior regions showing relative selectivity for rewards and more posterior regions for losses. These findings mirror the anteroposterior valence-specific gradient reported in rodents and endorse the role of the striatum in aversive motivational learning about financial losses, illustrating functional and anatomical consistencies with primary aversive outcomes such as pain.

Original publication

DOI

10.1523/jneurosci.0400-07.2007

Type

Journal article

Journal

The Journal of neuroscience : the official journal of the Society for Neuroscience

Publication Date

05/2007

Volume

27

Pages

4826 - 4831

Addresses

Wellcome Trust Centre for Neuroimaging, UCL, London, United Kingdom. bseymour@fil.ion.ucl.ac.uk

Keywords

Corpus Striatum, Humans, Brain Mapping, Photic Stimulation, Conditioning, Classical, Reward, Adult, Female, Male