Cohort profile: a collaborative multicentre study of retinal optical coherence tomography in 539 patients with neuromyelitis optica spectrum disorders (CROCTINO).
Specovius S., Zimmermann HG., Oertel FC., Chien C., Bereuter C., Cook LJ., Lana Peixoto MA., Fontenelle MA., Kim HJ., Hyun J-W., Jung S-K., Palace J., Roca-Fernandez A., Diaz AR., Leite MI., Sharma SM., Ashtari F., Kafieh R., Dehghani A., Pourazizi M., Pandit L., Dcunha A., Aktas O., Ringelstein M., Albrecht P., May E., Tongco C., Leocani L., Pisa M., Radaelli M., Martinez-Lapiscina EH., Stiebel-Kalish H., Hellmann M., Lotan I., Siritho S., de Seze J., Senger T., Havla J., Marignier R., Tilikete C., Cobo Calvo A., Bichuetti DB., Tavares IM., Asgari N., Soelberg K., Altintas A., Yildirim R., Tanriverdi U., Jacob A., Huda S., Rimler Z., Reid A., Mao-Draayer Y., de Castillo IS., Yeaman MR., Smith TJ., Brandt AU., Paul F., GJCF International Clinical Consortium for NMOSD None.
PURPOSE: Optical coherence tomography (OCT) captures retinal damage in neuromyelitis optica spectrum disorders (NMOSD). Previous studies investigating OCT in NMOSD have been limited by the rareness and heterogeneity of the disease. The goal of this study was to establish an image repository platform, which will facilitate neuroimaging studies in NMOSD. Here we summarise the profile of the Collaborative OCT in NMOSD repository as the initial effort in establishing this platform. This repository should prove invaluable for studies using OCT to investigate NMOSD. PARTICIPANTS: The current cohort includes data from 539 patients with NMOSD and 114 healthy controls. These were collected at 22 participating centres from North and South America, Asia and Europe. The dataset consists of demographic details, diagnosis, antibody status, clinical disability, visual function, history of optic neuritis and other NMOSD defining attacks, and OCT source data from three different OCT devices. FINDINGS TO DATE: The cohort informs similar demographic and clinical characteristics as those of previously published NMOSD cohorts. The image repository platform and centre network continue to be available for future prospective neuroimaging studies in NMOSD. For the conduct of the study, we have refined OCT image quality criteria and developed a cross-device intraretinal segmentation pipeline. FUTURE PLANS: We are pursuing several scientific projects based on the repository, such as analysing retinal layer thickness measurements, in this cohort in an attempt to identify differences between distinct disease phenotypes, demographics and ethnicities. The dataset will be available for further projects to interested, qualified parties, such as those using specialised image analysis or artificial intelligence applications.