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<jats:sec> <jats:title>Background and Purpose:</jats:title> <jats:p>Intraluminal thrombus (ILT) is an emerging imaging marker in acute ischemic stroke. We aimed to investigate the association of ILT with outcomes of acute large vessel occlusion (LVO) patients receiving endovascular treatment.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods:</jats:title> <jats:p>Acute LVO stroke patients who underwent endovascular treatment within 24 hours, in a prospective, nationwide registry were enrolled. Pretreatment digital subtraction angiography was reviewed for the presence of ILT. The primary outcome was 90-day functional dependence (modified Rankin Scale scores, 3–6). Secondary outcomes included 24-hour LVO, 90-day death, and symptomatic intracranial hemorrhage.</jats:p> </jats:sec> <jats:sec> <jats:title>Results:</jats:title> <jats:p> Among 711 patients enrolled, 75 (10.5%) with ILT were less likely to have 90-day functional dependence compared with those without ILT (adjusted odds ratio, 0.53 [95% CI, 0.31–0.90]; <jats:italic>P</jats:italic> =0.021). The same trend was found among those with successful reperfusion (modified Thrombolysis in Cerebral Infarction 2b–3; <jats:italic>P</jats:italic> =0.008) but not in those without successful reperfusion ( <jats:italic>P</jats:italic> =0.107). Presence of ILT was also independently associated with a lower rate of 24-hour LVO (adjusted odds ratio 0.34 [95% CI, 0.13–0.89]; <jats:italic>P</jats:italic> =0.028). However, those with or without ILT had similar risks of symptomatic intracranial hemorrhage and 90-day death. </jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions:</jats:title> <jats:p>Among acute LVO patients receiving endovascular treatment, pretreatment ILT-positive patients may have a better 90-day functional outcome (versus ILT-negative) but similar risk of death and symptomatic intracranial hemorrhage. The possibly favorable effect of ILT patients remained in those with successful reperfusion.</jats:p> </jats:sec> <jats:sec> <jats:title>Registration:</jats:title> <jats:p> URL: <jats:ext-link xmlns:xlink="" ext-link-type="uri" xlink:href=""></jats:ext-link> ; Unique identifier: ChiCTR1900022154. </jats:p> </jats:sec>

Original publication




Journal article




Ovid Technologies (Wolters Kluwer Health)

Publication Date





1473 - 1477