Vancomycin Is Protective in a Neonatal Mouse Model of Staphylococcus epidermidis -Potentiated Hypoxic-Ischemic Brain Injury
Lai JCY., Svedin P., Ek CJ., Mottahedin A., Wang X., Levy O., Currie A., Strunk T., Mallard C.
Infection is correlated with increased risk of neurodevelopmental sequelae in preterm infants. In modeling neonatal brain injury, Toll-like receptor agonists have often been used to mimic infections and induce inflammation. Using the most common cause of bacteremia in preterm infants, Staphylococcus epidermidis , we present a more clinically relevant neonatal mouse model that addresses the combined effects of bacterial infection together with subsequent hypoxic-ischemic brain insult.