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AimGadolinium-based nanoparticles were functionalized with either the Pittsburgh compound B or a nanobody (B10AP) in order to create multimodal tools for an early diagnosis of amyloidoses.Materials & methodsThe ability of the functionalized nanoparticles to target amyloid fibrils made of β-amyloid peptide, amylin or Val30Met-mutated transthyretin formed in vitro or from pathological tissues was investigated by a range of spectroscopic and biophysics techniques including fluorescence microscopy.ResultsNanoparticles functionalized by both probes efficiently interacted with the three types of amyloid fibrils, with KD values in 10 micromolar and 10 nanomolar range for, respectively, Pittsburgh compound B and B10AP nanoparticles. Moreover, they allowed the detection of amyloid deposits on pathological tissues.ConclusionSuch functionalized nanoparticles could represent promising flexible and multimodal imaging tools for the early diagnostic of amyloid diseases, in other words, Alzheimer's disease, Type 2 diabetes mellitus and the familial amyloidotic polyneuropathy.

Original publication




Journal article


Nanomedicine (London, England)

Publication Date





1675 - 1687


Laboratoire de Chimie et Biologie des Métaux, Université Grenoble Alpes, CEA Life Sciences Division, CNRS, 17 rue des Martyrs, 38054 Grenoble Cedex 9, France.


Brain, Animals, Humans, Mice, Alzheimer Disease, Diabetes Mellitus, Type 2, Gadolinium, Aniline Compounds, Thiazoles, Immunohistochemistry, Nanoparticles, Amyloid beta-Peptides, Plaque, Amyloid, Islet Amyloid Polypeptide, Single-Domain Antibodies, Multimodal Imaging