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We hypothesized that knowledge of cerebral autoregulation (CA) status during recanalization therapies could guide further studies aimed at neuroprotection targeting penumbral tissue, especially in patients that do not respond to therapy. Thus, we assessed CA status of patients with acute ischemic stroke (AIS) during intravenous r-tPA therapy and associated CA with response to therapy. AIS patients eligible for intravenous r-tPA therapy were recruited. Cerebral blood flow velocities (transcranial Doppler) from middle cerebral artery and blood pressure (Finometer) were recorded to calculate the autoregulation index (ARI, as surrogate for CA). National Institute of Health Stroke Score was assessed and used to define responders to therapy (improvement of ≥ 4 points on NIHSS measured 24-48 h after therapy). CA was considered impaired if ARI 

Original publication




Journal article


Scientific reports

Publication Date





Neurology Department, School of Medicine, Hospital das Clinicas, University of São Paulo, São Paulo, 01246-904, Brazil.


Middle Cerebral Artery, Humans, Brain Ischemia, Infarction, Middle Cerebral Artery, Ultrasonography, Doppler, Transcranial, Blood Flow Velocity, Treatment Outcome, Thrombolytic Therapy, Severity of Illness Index, Homeostasis, Fibrinolysis, Blood Pressure, Cerebrovascular Circulation, Aged, Aged, 80 and over, Middle Aged, Female, Male, Stroke, Administration, Intravenous, Ischemic Stroke