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In rheumatic pain there is good evidence that topical nonsteroidal anti-inflammatory drugs are about as effective as oral nonsteroidal anti-inflammatory drugs, but are probably safer and more tolerable because of much less systemic absorption and lower plasma concentrations. The best information is for topical diclofenac. For topical capsaicin, evidence of efficacy is trivial. For topical rubefacients there is no evidence of efficacy.

Original publication

DOI

10.1016/j.rdc.2008.03.006

Type

Journal article

Journal

Rheum Dis Clin North Am

Publication Date

05/2008

Volume

34

Pages

415 - 432

Keywords

Administration, Cutaneous, Anti-Inflammatory Agents, Non-Steroidal, Capsaicin, Clinical Trials as Topic, Humans, Irritants, Pain, Rheumatic Diseases, Sensory System Agents