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We examined the findings from single-fiber electromyography in extensor digitorum communis (EDC) and orbicularis oculi (OOc) in 13 myasthenia gravis (MG) patients with muscle-specific kinase antibodies (MuSK-MG) and 12 MG patients with acetylcholine receptor antibodies (AChR-MG) with similar clinical scores. More than 70% of AChR-MG patients had abnormal jitter in both EDC and OOc, but the majority of MuSK-MG patients had normal jitter in EDC despite abnormal jitter in OOc. These findings demonstrate clear differences between the neurophysiology of MuSK-MG and AChR-MG.

Original publication

DOI

10.1002/mus.20491

Type

Journal article

Journal

Muscle Nerve

Publication Date

04/2006

Volume

33

Pages

568 - 570

Keywords

Acetylcholinesterase, Antibodies, Disability Evaluation, Electromyography, Electrophysiology, Extremities, Facial Muscles, Humans, Muscle Fibers, Skeletal, Muscle, Skeletal, Myasthenia Gravis, Neurologic Examination, Receptor Protein-Tyrosine Kinases, Receptors, Cholinergic