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PURPOSE OF REVIEW: To review the recent literature describing the detection and clinical importance of serum antibodies in patients with various epilepsies and other seizure-related disorders. RECENT FINDINGS: Auto-antibodies to the NMDA, GABAB and AMPA receptors and to LGI1, CASPR2 and Contactin-2, components of the voltage-gated potassium channel complex, have been detected in the serum of patients with seizures. These antigenic targets are ion channels, receptors and accessory proteins important in both cellular homeostasis and governing the electrical activity of the brain. Antibodies to glutamic acid decarboxylase (GAD) have been found in patients with temporal lobe epilepsy. Antibodies to LGI1 have been described in around 90% of patients with the newly described epileptic syndrome of faciobrachial dystonic seizures. SUMMARY: An increasing number of antibodies have been described in the epilepsies and other seizure-related disorders. Evidence of direct pathogenicity comes from the extracellular domain targeted by all of these antibodies (other than GAD) and the often dramatic clinical and serological response to immunotherapies, when antiepileptic drugs may be ineffective. Definitive proof as to the pathological relevance of these antibodies will be achieved in the generation of an animal model that demonstrates the clinical phenotype of these antibody-mediated disorders.

Original publication

DOI

10.1097/WCO.0b013e3283446f05

Type

Journal article

Journal

Curr Opin Neurol

Publication Date

04/2011

Volume

24

Pages

146 - 153

Keywords

Animals, Autoantibodies, Autoimmune Diseases, Clinical Trials as Topic, Contactins, Encephalitis, Epilepsy, Humans, Membrane Proteins, Nerve Tissue Proteins, Potassium Channels, Voltage-Gated, Proteins, Receptors, AMPA, Receptors, N-Methyl-D-Aspartate