Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Inflammation is assumed to be the main driver of neurodegeneration in multiple sclerosis. However there is evidence that questions this hypothesis: Data from pathological studies and from imaging have shown that neuronal/axonal damage occurs early in lesion formation and at the earliest clinical stage of the disease. Additionally axonal damage itself can lead to inflammation and laboratory and clinical observations suggest that inflammation may be neuroprotective. Finally, clinical trials reveal that immunosuppression does not have the predicted effect on axonal damage and disability. Clearly if inflammation is not the primary event but a secondary phenomenon this has important implications in developing treatment regimes.

Original publication




Journal article


J neurol sci

Publication Date





46 - 49


Humans, Inflammation, Neurodegenerative Diseases, Treatment Outcome