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We have developed a system to automatically acquire large numbers of acceptable quality images from specimens of negatively stained catalase, a biological protein which forms crystals. In this paper we will describe the details of the system architecture and analyze the performance of the system as compared to a human operator. The ultimate goal of the system if to automate the process of acquiring cryo-electron micrographs.

Type

Journal article

Journal

Ultramicroscopy

Publication Date

07/1999

Volume

77

Pages

153 - 161

Keywords

Automation, Humans, Microscopy, Electron