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Genetic factors are known to influence susceptibility to multiple sclerosis (MS) but the genes involved are largely undefined. Here, we report an association study based on 200 patients and 200 controls from the Porto region in Portugal. A total of 3974 markers were successfully typed from which we have identified 46 markers showing evidence of association. When compared to a physical map three regions were found with two of these markers less than 1.5 Mb apart: chromosomes 6p21.3 (the MHC region), 6q14.1 and 7q34.

Type

Journal article

Journal

J Neuroimmunol

Publication Date

10/2003

Volume

143

Pages

116 - 119

Keywords

Adolescent, Aged, Case-Control Studies, DNA, Electrophoresis, Capillary, Female, Genetic Predisposition to Disease, Genetic Testing, Genetics, Population, Genome, Human, Humans, Male, Microsatellite Repeats, Middle Aged, Multiple Sclerosis, Polymerase Chain Reaction, Portugal