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BACKGROUND: Family history of MI is an established risk factor for coronary artery disease and subclinical atherosclerosis. Maternal MI and maternal stroke are more common in females than males presenting with acute coronary syndromes (ACS), suggesting sex-specific heritability, but the effects of family history on location and extent of coronary artery disease are unknown. METHODS: In a prospective, population-based study (Oxford Vascular Study) of all patients with ACS, family history data for stroke and MI were analysed by sex of proband and affected first degree relatives (FDRs), and coronary angiograms were reviewed, where available. RESULTS: Of 835 probands with one or more ACS, 623 (420 males) had incident events and complete family history data. 351 patients with incident events (56.3%; 266 males) underwent coronary angiography. Neither angiographic disease localization nor severity were associated with sex-of-parent/sex-of-offspring in men or women. CONCLUSIONS: Sex-specific family history data do not predict angiographic localization of coronary disease in patients presenting with ACS. Maternal stroke and maternal MI probably affect ACS in females by a mechanism unrelated to atherosclerosis or coronary anatomy. However, family history data may still be useful in risk prediction and prognosis of ACS.

Original publication

DOI

10.1016/j.atherosclerosis.2012.01.033

Type

Journal article

Journal

Atherosclerosis

Publication Date

04/2012

Volume

221

Pages

451 - 457

Keywords

Aged, Aged, 80 and over, Analysis of Variance, Chi-Square Distribution, Coronary Angiography, Coronary Artery Disease, England, Female, Genetic Predisposition to Disease, Heredity, Humans, Male, Middle Aged, Myocardial Infarction, Pedigree, Phenotype, Predictive Value of Tests, Prospective Studies, Regression Analysis, Risk Assessment, Risk Factors, Severity of Illness Index, Sex Factors, Stroke