Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

In a recent study, administration of granulocyte colony stimulating factor (G-CSF) increased neuromyelitis optica (NMO) lesions in mice. Here we report a patient whose first episode of NMO may have been exacerbated by inadvertent administration of G-CSF. Histological examination of brain and spinal cord samples from three other NMO patients revealed markedly increased expression of G-CSF in neurons located in and around the lesions, with little or no expression in multiple sclerosis lesions or normal white matter. Taken together, these cases support a detrimental role for G-CSF in NMO pathogenesis.

Original publication

DOI

10.1177/1352458512443994

Type

Journal article

Journal

Mult Scler

Publication Date

12/2012

Volume

18

Pages

1801 - 1803

Keywords

Adult, Filgrastim, Granulocyte Colony-Stimulating Factor, Humans, Male, Medication Errors, Neuromyelitis Optica, Recombinant Proteins