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Lambert-Eaton myasthenic syndrome (LEMS) developed in a patient with presumed chronic inflammatory demyelinating polyneuropathy (CIDP) and negative chest CT. Since antibodies against both Hu and voltage-gated calcium channel (VGCC) were detected, repeated chest CT was performed, which eventually showed a pulmonary mass lesion. Biopsy revealed small cell lung cancer (SCLC) indicating the importance of repeated chest CT in LEMS even when an existing autoimmune-like disease and negative CT may suggest an autoimmune origin. This is the first report of paraneoplastic CIDP and LEMS associated with anti-Hu, anti-VGCC and SCLC.

Type

Journal article

Journal

Ideggyogy Sz

Publication Date

30/09/2008

Volume

61

Pages

325 - 328

Keywords

Carcinoma, Small Cell, Demyelinating Diseases, ELAV Proteins, Female, Humans, Lambert-Eaton Myasthenic Syndrome, Lung Neoplasms, Middle Aged, Paraneoplastic Syndromes, Nervous System