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The presence of oligoclonal bands of IgG (OCB) in cerebrospinal fluid (CSF) is used to establish a diagnosis of multiple sclerosis (MS), but their specificity has remained an enigma since its first description over forty years ago. We now report that the use of lipid arrays identifies heteromeric complexes of myelin derived lipids as a prominent target for this intrathecal B cell response.

Original publication

DOI

10.1016/j.jneuroim.2011.08.002

Type

Journal article

Journal

J Neuroimmunol

Publication Date

15/09/2011

Volume

238

Pages

87 - 95

Keywords

Analysis of Variance, Animals, B-Lymphocytes, Cells, Cultured, Embryo, Mammalian, Humans, Immunoglobulin G, Lipid Metabolism, Multiple Sclerosis, Myelin Basic Protein, Myelin Sheath, O Antigens, Oligoclonal Bands, Rats, Rats, Sprague-Dawley, Spinal Cord