Seasonal variation, sub-type and prodromal illnesses in guillain-barre syndrome.
Brain S., Webb A., Zentar M., Turner MR.
Studies have produced contradictory evidence for seasonal variation in the incidence of Guillain-Barre Syndrome (GBS), possibly due to the potentially confounding factor of the prodromal illness, for example peaks in Winter following influenza balanced by peaks in Summer due to diarrhoeal disease. The morbidity and mortality of GBS is influenced by the subtype of neuronal pathology, which may also depend upon the nature of the prodromal illness, for example axonal forms being associated with Campylobacter jejuni infection. In an attempt to study these interactions, we performed a retrospective cohort study of admission for GBS at a large teaching hospital to identify seasonal variation in incidence, subtype and associated prodromal illness.