Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Quantification of a number of neurochemicals within localised regions of tissue has long been possible using Magnetic Resonance Spectroscopy (MRS). In recent years, MRS has increasingly been utilised as a method to indirectly assess neuronal activity in vivo, primarily via measurement of the major neurotransmitters glutamate and γ-aminobutyric acid (GABA). To date a number of studies have highlighted relationships between local GABA levels and behaviour, and have demonstrated the modulation of GABA by protocols designed to induce synaptic plasticity. This review aims to examine the literature on MRS-assessed GABA changes in synaptic plasticity, focussing on the primary motor cortex (M1), to relate these to animal studies on the role of GABA in synaptic plasticity, and to highlight some of the important outstanding questions in interpreting MRS findings. © 2013 Elsevier Inc.

Original publication




Journal article



Publication Date





19 - 27