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Over the past 50 years, well over 100 twin studies have focussed on understanding factors contributing to variability in normal sleep-wake characteristics and sleep disturbances. Whilst we have gained a great deal from these studies, there is still much to be learnt. Twin studies can be used in multiple ways to answer questions beyond simply estimating heritability. This paper provides a comprehensive review of some of the most important findings from twin studies relating to sleep to date, with a focus on studies investigating genetic and environmental influences contributing to i) objective and subjective measures of normal sleep characteristics (e.g., sleep stage organisation, sleep quality); as well as sleep disturbances and disorders such as dyssomnias (e.g., insomnia, narcolepsy) and parasomnias (e.g., sleepwalking, bruxism); ii) the persistence of sleep problems from childhood to adulthood, and the possibility that the aetiological influences on sleep change with age; iii) the associations between sleep disturbances, emotional, behavioural and health-related problems; and iv) processes of gene-environment correlation and interaction. We highlight avenues for further research, emphasising the need to further consider the aetiology of longitudinal associations between sleep disturbances and psychopathology; the genetic and environmental overlap between sleep and numerous phenotypes; and processes of gene-environment interplay and epigenetics.

Original publication

DOI

10.1016/j.smrv.2012.01.008

Type

Journal article

Journal

Sleep Med Rev

Publication Date

02/2013

Volume

17

Pages

29 - 40

Keywords

Adult, Age Factors, Aged, Child, Child Behavior Disorders, Diseases in Twins, Emotions, Epigenesis, Genetic, Gene-Environment Interaction, Genetic Research, Genotype, Health Status Indicators, Humans, Phenotype, Polysomnography, Sleep, Sleep Wake Disorders, Social Behavior, Twin Studies as Topic