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BACKGROUND: A 71-year-old female presented on 3 occasions with escalating pain in a congenitally blind eye. Examination revealed hypertensive uveitis with morning glory optic disc dysplasia and absence of a crystalline lens. There was no previous intraocular surgery or trauma. Intensive anti-hypertensive agents and topical steroids did not control intraocular pressure (IOP) or inflammation. RESULTS: Dilated fundus examination on the third clinical review revealed a luxated cataractous lens on the retina. Pars plana vitrectomy and fragmatome lensectomy controlled inflammation and IOP, with resolution of ocular pain. DISCUSSION: This is an exceptional case of phacogenic uveitis with secondary glaucoma occurring years after spontaneous crystalline lens luxation in a patient with morning glory syndrome. The embryological pathogenesis of morning glory syndrome and the significance of accelerated cataractogenesis and zonular weakness are discussed. Hypertensive uveitis with unexplained absence of a crystalline lens in a blind eye must prompt suspicion of delayed phacogenic uveitis following asymptomatic lens luxation.

Original publication




Journal article


Ocul Immunol Inflamm

Publication Date





394 - 397


Lens luxation, morning glory syndrome, optic dysplasia, phacogenic glaucoma, phacogenic uveitis, zonular weakness, Aged, Diagnosis, Differential, Female, Glaucoma, Humans, Intraocular Pressure, Lens Subluxation, Lens, Crystalline, Syndrome, Uveitis