Limitations in Clinical Translation of Nanoparticle-Based Gene Therapy.
Wong JKL., Mohseni R., Hamidieh AA., MacLaren RE., Habib N., Seifalian AM.
Organic nanoparticle-based (ONP) gene therapy is a potential strategy to cure human cancer. However, there are still many practical barriers before the promising results from in vitro and preclinical studies can be translated to clinical success. We discuss the reasons behind the hesitant uptake by the clinic.