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Mutant mice with retinal degeneration (rd/rd) were given 1-h pulses of light of varying brightness at times of the night when they would normally be active. The mutant mice showed a significantly greater inhibition of locomotor activity to light (negative masking) than wildtype controls. Lack of impairment, or even enhancement of negative masking suggests that this response may depend on sparing in retinally degenerate mice of the same receptor type that mediates clock resetting, because synchronization of the circadian system is known to be unimpaired in these mutants. With very dim light pulses, mutants did not change their activity, but wildtypes actually became more active (positive masking). Positive and negative masking appear to depend on different sensory and central processes.

Type

Journal article

Journal

J Comp Physiol A

Publication Date

04/1999

Volume

184

Pages

423 - 428

Keywords

Animals, Circadian Rhythm, Darkness, Genotype, Light, Male, Mice, Mice, Inbred C3H, Mice, Inbred C57BL, Mice, Inbred CBA, Motor Activity, Mutation, Photic Stimulation, Retinal Degeneration, Vision, Ocular