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<p>Parkinson’s disease is the second most common neurodegenerative disease without cure. It is characterized by α-synuclein accumulation and aggregation in dopaminergic and other types of neurons. Because α-synuclein accumulation leads to a toxic gain of function, its ectopic expression in <em>Drosophila</em> has been a useful in vivo model for testing modifiers of its toxicity. This chapter describes four assays: the rapid iterative negative geotaxis, rough eye phenotype, quantification of dopaminergic neuronal loss, and measurements of circadian effects.</p>

Original publication

DOI

10.1007/978-1-4939-9124-2_15

Type

Journal article

Journal

Methods in Molecular Biology

Publisher

Springer

Publication Date

16/02/2019

Volume

1948

Pages

199 - 208

Keywords

behavior, in vivo models, neurotoxicity, Drosophila, morphology analysis