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<jats:sec><jats:title>Background</jats:title><jats:p>There is uncertainty about the efficacy of lamotrigine in bipolar depressive episodes.</jats:p></jats:sec><jats:sec><jats:title>Aims</jats:title><jats:p>To synthesise the evidence for the efficacy of lamotrigine in bipolar depressive episodes.</jats:p></jats:sec><jats:sec><jats:title>Method</jats:title><jats:p>Systematic review and meta-analysis of individual patient data from randomised controlled trials comparing lamotrigine with placebo.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Individual data from 1072 participants from five randomised controlled trials were obtained. More individuals treated with lamotrigine than placebo responded to treatment on both the Hamilton Rating Scale for Depression (HRSD) (relative risk (RR)=1.27, 95% CI 1.09–1.47, <jats:italic>P</jats:italic>=0.002) and Montgomery– åsberg Depression Rating Scale (MADRS) (RR=1.22, 95% CI 1.06–1.41, <jats:italic>P</jats:italic>=0.005). There was an interaction (<jats:italic>P</jats:italic>=0.04) by baseline severity of depression: lamotrigine was superior to placebo in people with HRSD score &gt;24 (RR=1.47, 95% CI 1.16–1.87, <jats:italic>P</jats:italic>=0.001) but not in people with HRSD score 24 (RR=1.07, 95% CI 0.90–1.27, <jats:italic>P</jats:italic>=0.445).</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>There is consistent evidence that lamotrigine has a beneficial effect on depressive symptoms in the depressed phase of bipolar disorder. The overall pool effect was modest, although the advantage over placebo was larger in more severely depressed participants.</jats:p></jats:sec>

Original publication

DOI

10.1192/bjp.bp.107.048504

Type

Journal article

Journal

British Journal of Psychiatry

Publisher

Royal College of Psychiatrists

Publication Date

01/2009

Volume

194

Pages

4 - 9