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Contact information


alan.liu@ndcn.ox.ac.uk


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Biography

I graduated with an MBBS-PhD degree from Imperial College School of Medicine in 2018 with Distinctions in Medical Sciences, Clinical Science and Clinical Practice. My PhD was jointly awarded from Imperial College London and the University of Hong Kong with a thesis titled "Clinicopathological investigations of the cholinergic basal forebrain in Lewy body disorders and ageing".

I completed my foundation training at the North West of England Foundation School in Merseyside before being awarded an NIHR Academic Clinical Fellowship in Neurology at the University of Oxford. During my internal medicine training, I completed the membership exam for the Royal College of Physicians (MRCP). 

Currently, I am a specialty registrar in histopathology at the Thames Valley Deanery. I also hold honorary research roles at both the University of Oxford (Nuffield Department of Clinical Neurosciences) and Imperial College London (Division of Brain Sciences), where I remain actively involved in neuropathology research and supervision.


Alan King Lun Liu

MBBS PhD MRCP(UK)

Specialty Registrar in Histopathology and Honorary Post-Doctoral Researcher in neuropathology

Research interests

  • Neuropathology of Parkinson's disease and Lewy body dementia
  • Non-motor and non-dopaminergic aspects of Lewy body disorders
  • The cholinergic system in neurodegenerative diseases
  • Development and implementation of novel research techniques for translational neuropathology

Technical expertise

  • Dissection, histological processing and immunohistochemistry of human post-mortem brain tissues
  • Neuropathological assessment of neurodegenerative disease
  • Tissue clearing for three-dimensional visualisation of human and rodent brain tissues
  • Confocal microscopy

Current research projects

  • Investigating the morphology, distribution and burden of astrocytic alpha-synuclein aggregation in Parkinson’s disease and incidental Lewy body disease.

  • Revisiting the pathological staging of Parkinson’s disease using novel antibodies targeting different epitope sites and post-translational modifications of alpha-synuclein.

  • Optimisation of spatial transcriptomics on post-mortem human brain tissues to explore the role of regional transcriptomic changes on selective vulnerability of neuron and glial cells in Lewy body disorders.



Key publications

Recent publications

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