Amin Mottahedin
MSc, PhD, FHEA
Senior Research Fellow
We (Buchan's lab and Foster's lab) investigate how time-of-day affects stroke-induced brain injury. I am particularly interested in how metabolic responses to ischemia and hypoxia are affected by time of day and our circadian rhythm.
I completed my PhD in Medical Sciences from University of Gothenburg (Mallard's lab). During my studies, we revealed the mechanisms by which bacterial and viral infections exacerbate neonatal hypoxic-ischemic brain injury. After receiving an international postdoc fellowship from Swedish Research Council, I joined Mike Murphy's & Thomas Krieg's lab at University of Cambridge, where we were able to identify malonate as a potential therapeutic to reduce ischemia-reperfusion injury after stroke.
Contact information
Research groups
Colleges
Recent publications
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Stroke in the Time of Circadian Medicine
Journal article
Mergenthaler P. et al, (2024), Circulation Research, 134, 770 - 790
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Targeting succinate metabolism to decrease brain injury upon mechanical thrombectomy treatment of ischemic stroke
Journal article
Mottahedin A. et al, (2023), Redox Biology, 59, 102600 - 102600
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Two different isoforms of osteopontin modulate myelination and axonal integrity
Journal article
Nilsson G. et al, (2023), FASEB BIOADVANCES
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Scavenger receptor CD36 governs recruitment of myeloid cells to the blood–CSF barrier after stroke in neonatal mice
Journal article
Rayasam A. et al, (2022), Journal of Neuroinflammation, 19
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ND3 Cys39 in complex I is exposed during mitochondrial respiration
Journal article
Burger N. et al, (2022), Cell Chemical Biology, 29, 636 - 649.e14