MSc, PhD, FHEA
Postdoctoral Research Associate
I work with Foster's lab at Nuffield Department of Clinical Neurosciences (NDCN) and Buchan’s lab at Radcliffe Department of Medicine to unravel the effect of circadian rhythm on stroke-induced brain injury, in a trans-Atlantic collaborative project supported by Leducq foundation. I am particularly interested in how metabolic responses to ischemia and hypoxia are affected by circadian rhythm.
I was a veterinarian in my home country, Iran, before moving to Sweden to start my science journey. I obtained a master’s degree in Infection Biology from Uppsala University and completed my PhD in Medical Sciences from University of Gothenburg (Mallard's lab) in 2017. During my PhD, I investigated how infection/ inflammation affects the developing brain and exacerbates the hypoxic-ischemic brain injury. After receiving an international postdoc grant from Swedish Research Council, I moved to MRC Mitochondrial Biology Unit (Murphy's & Krieg's lab) at University of Cambridge, where we were able to identify mitochondrial succinate metabolism as a potential therapeutic target in ischemic stroke.
Targeting succinate metabolism to decrease brain injury upon mechanical thrombectomy treatment of ischemic stroke
Mottahedin A. et al, (2023), Redox Biology, 59, 102600 - 102600
Two different isoforms of osteopontin modulate myelination and axonal integrity
Nilsson G. et al, (2023), FASEB BIOADVANCES
Scavenger receptor CD36 governs recruitment of myeloid cells to the blood–CSF barrier after stroke in neonatal mice
Rayasam A. et al, (2022), Journal of Neuroinflammation, 19
ND3 Cys39 in complex I is exposed during mitochondrial respiration
Burger N. et al, (2022), Cell Chemical Biology, 29, 636 - 649.e14
Structural basis for a complex I mutation that blocks pathological ROS production.
Yin Z. et al, (2021), Nat Commun, 12