Amin Mottahedin
MSc, PhD, FHEA
Senior Research Fellow
We (Buchan's lab and Foster's lab) investigate how time-of-day affects stroke-induced brain injury. I am particularly interested in how metabolic responses to ischemia and hypoxia are affected by time of day and our circadian rhythm.
I completed my PhD in Medical Sciences from University of Gothenburg (Mallard's lab). During my studies, we revealed the mechanisms by which bacterial and viral infections exacerbate neonatal hypoxic-ischemic brain injury. After receiving an international postdoc fellowship from Swedish Research Council, I joined Mike Murphy's & Thomas Krieg's lab at University of Cambridge, where we were able to identify malonate as a potential therapeutic to reduce ischemia-reperfusion injury after stroke.
Contact information
Colleges
Recent publications
Multimodal molecular profiling of the metabolic penumbra in hyperacute stroke
Preprint
Mottahedin A. et al, (2026)
Measuring cerebral glucose metabolism by chemical exchange-sensitive spin-lock (CESL) MRI of 2-deoxy-D-glucose in rodents
Journal article
Boehm-Sturm P. et al, (2026), PLOS One, 21, e0346046 - e0346046
2-deoxy-D-glucose chemical exchange-sensitive spin-lock MRI of cerebral glucose metabolism after transient focal stroke in the rat
Journal article
Boehm-Sturm P. et al, (2025), Journal of Cerebral Blood Flow & Metabolism, 45, 2370 - 2380
Local arterial administration of acidified malonate as an adjunct therapy to mechanical thrombectomy in ischemic stroke
Journal article
Lee JJ. et al, (2025), Cardiovascular Research, 121, 1407 - 1418
2-deoxy-D-glucose chemical exchange-sensitive spin-lock MRI of cerebral glucose metabolism after stroke in the rat
Preprint
Boehm-Sturm P. et al, (2025)