Andreas Themistocleous

BSc(Hons), MBBCh, PhD, FCP (SA), MRCP (UK)

Clinical Lecturer in Neurophysiology

Research Summary

My research is focused on understanding the mechanisms of neuropathic pain. I use a combination of techniques, such as threshold tracking, intraepidermal nerve fibre density assessment and quantitative sensory testing, to assess the functional and structural integrity of the peripheral nervous system. These techniques allow me to explore peripheral neuronal processing in patients suffering from peripheral neuropathy. Most of my current research is focused on characterising the somatosensory, histological and electrophysiological phenotype of patients with diabetic neuropathic pain.

Key publications

Chronic non-freezing cold injury results in neuropathic pain due to a sensory neuropathy
Journal article

Vale TA. et al, (2017), Brain, 140, 2557 - 2569
Rare NaV1.7 variants associated with painful diabetic peripheral neuropathy
Journal article

Blesneac I. et al, (2018), PAIN, 159, 469 - 480
The Pain in Neuropathy Study (PiNS)
Journal article

Themistocleous AC. et al, (2016), PAIN, 157, 1132 - 1145
A brain-based pain facilitation mechanism contributes to painful diabetic polyneuropathy
Journal article

Segerdahl AR. et al, (2018), Brain, 141, 357 - 364
Defining the Functional Role of NaV1.7 in Human Nociception
Journal article

McDermott LA. et al, (2019), Neuron, 101, 905 - 919.e8

Recent publications

Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial
Journal article

Folegatti PM. et al, (2020), The Lancet, 396, 467 - 478
Long-term symptoms of polyneuropathy in breast and colorectal cancer patients treated with and without adjuvant chemotherapy.
Journal article

Bennedsgaard K. et al, (2020), Cancer Med, 9, 5114 - 5123
Whole-genome sequencing of a sporadic primary immunodeficiency cohort
Journal article

Thaventhiran JED. et al, (2020), Nature, 583, 90 - 95
Whole-genome sequencing of patients with rare diseases in a national health system.
Journal article

Turro E. et al, (2020), Nature, 583, 96 - 102
Cold aggravates abnormal excitability of motor axons in oxaliplatin-treated patients.
Journal article

Bennedsgaard K. et al, (2020), Muscle Nerve, 61, 796 - 800

More publications