Andreas Themistocleous
MBBCh, PhD, FCP (SA)
Clinical Research Fellow
Research Summary
My research is focussed on understanding the mechanisms of neuropathic pain. I use a combination of techniques, such as threshold tracking, intraepidermal nerve fibre density assessment and quantitative sensory testing, to assess the functional and structural integrity of the peripheral nervous system. These techniques allow me to explore peripheral neuronal processing in patients suffering from peripheral neuropathy. Most of my current research is focused on characterising the somatosensory, histological and electrophysiological phenotype of patients with diabetic neuropathic pain.
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Stratifying patients with peripheral neuropathic pain based on sensory profiles: algorithm and sample size recommendations.
Vollert J. et al, (2017), Pain, 158, 1446 - 1455
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Rare Variants in MME, Encoding Metalloprotease Neprilysin, Are Linked to Late-Onset Autosomal-Dominant Axonal Polyneuropathies.
Auer-Grumbach M. et al, (2016), Am J Hum Genet, 99, 607 - 623
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The Pain in Neuropathy Study (PiNS): a cross-sectional observational study determining the somatosensory phenotype of painful and painless diabetic neuropathy.
Themistocleous AC. et al, (2016), Pain, 157, 1132 - 1145
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Corrigendum: Transcriptional regulator PRDM12 is essential for human pain perception.
Chen YC. et al, (2015), Nat Genet, 47
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Transcriptional regulator PRDM12 is essential for human pain perception.
Chen YC. et al, (2015), Nat Genet, 47, 803 - 808