Research groups
Collaborators
Colleges
Andreas Themistocleous
BSc(Hons), MBBCh, PhD, FCP (SA), MRCP (UK)
MRC Clinician Scientist Fellow
Research Summary
My research is focused on understanding the mechanisms of neuropathic pain. I use a combination of techniques, such as microneurography, threshold tracking, intraepidermal nerve fibre density assessment and quantitative sensory testing, to assess the functional and structural integrity of the peripheral nervous system. These techniques allow me to explore peripheral neuronal processing in patients suffering from peripheral neuropathy. Most of my current research is focused on characterising the somatosensory, histological and electrophysiological phenotype of patients with diabetic neuropathic pain.
Key publications
Defining the Functional Role of NaV1.7 in Human Nociception
Journal article
McDermott LA. et al, (2019), Neuron, 101, 905 - 919.e8
Rare NaV1.7 variants associated with painful diabetic peripheral neuropathy
Journal article
Blesneac I. et al, (2018), Pain, 159, 469 - 480
A brain-based pain facilitation mechanism contributes to painful diabetic polyneuropathy
Journal article
Segerdahl AR. et al, (2018), Brain, 141, 357 - 364
Chronic non-freezing cold injury results in neuropathic pain due to a sensory neuropathy
Journal article
Vale TA. et al, (2017), Brain, 140, 2557 - 2569
The Pain in Neuropathy Study (PiNS)
Journal article
Themistocleous AC. et al, (2016), Pain, 157, 1132 - 1145
Recent publications
Understanding sensory abnormalities in fibromyalgia through autoantibodies
Journal article
Themistocleous AC. et al, (2025), Brain, 148, 3792 - 3794
The double-edged scalpel: genome-wide association studies and chronic postsurgical pain.
Journal article
Themistocleous AC. and Li W., (2025), Anaesthesia, 80, 753 - 756
Harmonizing neuropathic pain research: outcomes of the London consensus meeting on peripheral tissue studies
Journal article
Villa S. et al, (2025), Pain, 166, 994 - 1001
Serum Neurofilament Light Chain and Structural and Functional Nerve Fiber Loss in Painful and Painless Diabetic Polyneuropathy.
Journal article
Määttä LL. et al, (2025), Diabetes Res Clin Pract, 223
Immunotherapy‐Resistant Neuropathic Pain and Fatigue Predict Quality‐of‐Life in Contactin‐Associated Protein‐Like 2 Antibody Disease
Journal article
Ceronie B. et al, (2025), Annals of Neurology, 97, 521 - 528