Research groups
Andreas Themistocleous
BSc(Hons), MBBCh, PhD, FCP (SA), MRCP (UK)
Clinical Lecturer in Neurophysiology
Research Summary
My research is focused on understanding the mechanisms of neuropathic pain. I use a combination of techniques, such as microneurography, threshold tracking, intraepidermal nerve fibre density assessment and quantitative sensory testing, to assess the functional and structural integrity of the peripheral nervous system. These techniques allow me to explore peripheral neuronal processing in patients suffering from peripheral neuropathy. Most of my current research is focused on characterising the somatosensory, histological and electrophysiological phenotype of patients with diabetic neuropathic pain.
Key publications
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Chronic non-freezing cold injury results in neuropathic pain due to a sensory neuropathy
Journal article
Vale TA. et al, (2017), Brain, 140, 2557 - 2569
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Rare NaV1.7 variants associated with painful diabetic peripheral neuropathy
Journal article
Blesneac I. et al, (2018), Pain, 159, 469 - 480
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The Pain in Neuropathy Study (PiNS)
Journal article
Themistocleous AC. et al, (2016), PAIN, 157, 1132 - 1145
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A brain-based pain facilitation mechanism contributes to painful diabetic polyneuropathy
Journal article
Segerdahl AR. et al, (2018), Brain, 141, 357 - 364
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Defining the Functional Role of NaV1.7 in Human Nociception
Journal article
McDermott LA. et al, (2019), Neuron, 101, 905 - 919.e8
Recent publications
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Acute small fiber neuropathy after Oxford‐AstraZeneca ChAdOx1‐S vaccination: A report of three cases and review of the literature
Journal article
Abbott MG. et al, (2022), Journal of the Peripheral Nervous System
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Classification of painful or painless diabetic peripheral neuropathy and identification of the most powerful predictors using machine learning models in large cross-sectional cohorts
Journal article
BASKOZOS G., (2022), BMC Medical Informatics and Decision Making
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Malleability of the cortical hand map following a finger nerve block.
Journal article
Wesselink DB. et al, (2022), Sci Adv, 8
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Axonal excitability does not differ between painful and painless diabetic or chemotherapy-induced distal symmetrical polyneuropathy in a multi-centre observational study.
Journal article
Themistocleous AC. et al, (2022), Ann Neurol
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Nav1.7 is required for normal C-low threshold mechanoreceptor function in humans and mice
Journal article
Middleton SJ. et al, (2021), Brain