Andreas Themistocleous

BSc(Hons), MBBCh, PhD, FCP (SA), MRCP (UK)

Clinical Lecturer in Neurophysiology

Research Summary

My research is focused on understanding the mechanisms of neuropathic pain. I use a combination of techniques, such as threshold tracking, intraepidermal nerve fibre density assessment and quantitative sensory testing, to assess the functional and structural integrity of the peripheral nervous system. These techniques allow me to explore peripheral neuronal processing in patients suffering from peripheral neuropathy. Most of my current research is focused on characterising the somatosensory, histological and electrophysiological phenotype of patients with diabetic neuropathic pain.

Key publications

Chronic non-freezing cold injury results in neuropathic pain due to a sensory neuropathy
Journal article

Vale TA. et al, (2017), Brain, 140, 2557 - 2569
Rare NaV1.7 variants associated with painful diabetic peripheral neuropathy
Journal article

Blesneac I. et al, (2018), PAIN, 159, 469 - 480
The Pain in Neuropathy Study (PiNS)
Journal article

Themistocleous AC. et al, (2016), PAIN, 157, 1132 - 1145
A brain-based pain facilitation mechanism contributes to painful diabetic polyneuropathy
Journal article

Segerdahl AR. et al, (2018), Brain, 141, 357 - 364
Defining the Functional Role of NaV1.7 in Human Nociception
Journal article

McDermott LA. et al, (2019), Neuron, 101, 905 - 919.e8

Recent publications

Axonal swellings are related to type 2 diabetes, but not to distal diabetic sensorimotor polyneuropathy
Journal article

Karlsson P. et al, (2021), Diabetologia
Phase 1/2 trial of SARS-CoV-2 vaccine ChAdOx1 nCoV-19 with a booster dose induces multifunctional antibody responses
Journal article

Barrett JR. et al, (2020), Nature Medicine
T cell and antibody responses induced by a single dose of ChAdOx1 nCoV-19 (AZD1222) vaccine in a phase 1/2 clinical trial
Journal article

Ewer KJ. et al, (2020), Nature Medicine
Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK
Journal article

Voysey M. et al, (2020), The Lancet
Safety and immunogenicity of ChAdOx1 nCoV-19 vaccine administered in a prime-boost regimen in young and old adults (COV002): a single-blind, randomised, controlled, phase 2/3 trial
Journal article

Ramasamy MN. et al, (2020), The Lancet, 396, 1979 - 1993

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