Research groups
Collaborators
Colleges
Andreas Themistocleous
BSc(Hons), MBBCh, PhD, FCP (SA), MRCP (UK)
MRC Clinician Scientist Fellow
Research Summary
My research is focused on understanding the mechanisms of neuropathic pain. I use a combination of techniques, such as microneurography, threshold tracking, intraepidermal nerve fibre density assessment and quantitative sensory testing, to assess the functional and structural integrity of the peripheral nervous system. These techniques allow me to explore peripheral neuronal processing in patients suffering from peripheral neuropathy. Most of my current research is focused on characterising the somatosensory, histological and electrophysiological phenotype of patients with diabetic neuropathic pain.
Key publications
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Chronic non-freezing cold injury results in neuropathic pain due to a sensory neuropathy
Vale TA. et al, (2017), Brain, 140, 2557 - 2569
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Rare NaV1.7 variants associated with painful diabetic peripheral neuropathy
Blesneac I. et al, (2018), Pain, 159, 469 - 480
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The Pain in Neuropathy Study (PiNS)
Themistocleous AC. et al, (2016), PAIN, 157, 1132 - 1145
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A brain-based pain facilitation mechanism contributes to painful diabetic polyneuropathy
Segerdahl AR. et al, (2018), Brain, 141, 357 - 364
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Defining the Functional Role of NaV1.7 in Human Nociception
McDermott LA. et al, (2019), Neuron, 101, 905 - 919.e8
Recent publications
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Eleven neurology-related proteins measured in serum are positively correlated to the severity of diabetic neuropathy
Bäckryd E. et al, (2024), Scientific Reports, 14
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Genetic associations of neuropathic pain and sensory profile in a deeply phenotyped neuropathy cohort
BASKOZOS G. et al, (2024), Pain
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Mechanisms of neurodynamic treatments (MONET): a protocol for a mechanistic, randomised, single-blind controlled trial in patients with carpal tunnel syndrome
E. S-S. et al, (2024), BMC Musculoskeletal Disorders, 25
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What is associated with painful polyneuropathy? A cross-sectional analysis of symptoms and signs in patients with painful and painless polyneuropathy.
Gierthmühlen J. et al, (2024), Pain
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Can euglycemic Diabetic Ketoacidosis Caused by SGLT2 Inhibitors be avoided in Covid-19 and other acute Infections?
Pilianidis G. et al, (2024), Eur J Case Rep Intern Med, 11