Research groups
Andreas Themistocleous
BSc(Hons), MBBCh, PhD, FCP (SA), MRCP (UK)
Clinical Lecturer in Neurophysiology
Research Summary
My research is focused on understanding the mechanisms of neuropathic pain. I use a combination of techniques, such as microneurography, threshold tracking, intraepidermal nerve fibre density assessment and quantitative sensory testing, to assess the functional and structural integrity of the peripheral nervous system. These techniques allow me to explore peripheral neuronal processing in patients suffering from peripheral neuropathy. Most of my current research is focused on characterising the somatosensory, histological and electrophysiological phenotype of patients with diabetic neuropathic pain.
Key publications
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Chronic non-freezing cold injury results in neuropathic pain due to a sensory neuropathy
Journal article
Vale TA. et al, (2017), Brain, 140, 2557 - 2569
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Rare NaV1.7 variants associated with painful diabetic peripheral neuropathy
Journal article
Blesneac I. et al, (2018), Pain, 159, 469 - 480
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The Pain in Neuropathy Study (PiNS)
Journal article
Themistocleous AC. et al, (2016), PAIN, 157, 1132 - 1145
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A brain-based pain facilitation mechanism contributes to painful diabetic polyneuropathy
Journal article
Segerdahl AR. et al, (2018), Brain, 141, 357 - 364
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Defining the Functional Role of NaV1.7 in Human Nociception
Journal article
McDermott LA. et al, (2019), Neuron, 101, 905 - 919.e8
Recent publications
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Estimating motor unit numbers from a CMAP scan: Repeatability study on three muscles at 15 centres.
Journal article
Sørensen DM. et al, (2023), Clin Neurophysiol, 151, 92 - 99
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Utilising clinical parameters to improve the selection of nerve biopsy candidates
Journal article
Kopanidis P. et al, (2023), Internal Medicine Journal
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Investigating genotype-phenotype relationship of extreme neuropathic pain disorders in a UK national cohort
Journal article
Themistocleous AC. et al, (2023), Brain Communications
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The epidemiology of neuropathic pain: an analysis of prevalence and associated factors in UK Biobank
Journal article
BASKOZOS G. et al, (2022), PAIN Reports
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Acute small fiber neuropathy after Oxford‐AstraZeneca ChAdOx1‐S vaccination: A report of three cases and review of the literature
Journal article
Abbott MG. et al, (2022), Journal of the Peripheral Nervous System, 27, 325 - 329