Research groups
Collaborators
Colleges
Andreas Themistocleous
BSc(Hons), MBBCh, PhD, FCP (SA), MRCP (UK)
MRC Clinician Scientist Fellow
Research Summary
My research is focused on understanding the mechanisms of neuropathic pain. I use a combination of techniques, such as microneurography, threshold tracking, intraepidermal nerve fibre density assessment and quantitative sensory testing, to assess the functional and structural integrity of the peripheral nervous system. These techniques allow me to explore peripheral neuronal processing in patients suffering from peripheral neuropathy. Most of my current research is focused on characterising the somatosensory, histological and electrophysiological phenotype of patients with diabetic neuropathic pain.
Key publications
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Chronic non-freezing cold injury results in neuropathic pain due to a sensory neuropathy
Journal article
Vale TA. et al, (2017), Brain, 140, 2557 - 2569
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Rare NaV1.7 variants associated with painful diabetic peripheral neuropathy
Journal article
Blesneac I. et al, (2018), Pain, 159, 469 - 480
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The Pain in Neuropathy Study (PiNS)
Journal article
Themistocleous AC. et al, (2016), PAIN, 157, 1132 - 1145
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A brain-based pain facilitation mechanism contributes to painful diabetic polyneuropathy
Journal article
Segerdahl AR. et al, (2018), Brain, 141, 357 - 364
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Defining the Functional Role of NaV1.7 in Human Nociception
Journal article
McDermott LA. et al, (2019), Neuron, 101, 905 - 919.e8
Recent publications
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The double-edged scalpel: genome-wide association studies and chronic postsurgical pain.
Journal article
Themistocleous AC. and Li W., (2025), Anaesthesia
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Serum neurofilament light chain and structural and Functional nerve fiber loss in painful and painless diabetic polyneuropathy.
Journal article
Määttä LL. et al, (2025), Diabetes Res Clin Pract
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Immunotherapy‐Resistant Neuropathic Pain and Fatigue Predict Quality‐of‐Life in Contactin‐Associated Protein‐Like 2 Antibody Disease
Journal article
Ceronie B. et al, (2025), Annals of Neurology
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Eleven neurology-related proteins measured in serum are positively correlated to the severity of diabetic neuropathy
Journal article
Bäckryd E. et al, (2024), Scientific Reports, 14
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Genetic associations of neuropathic pain and sensory profile in a deeply phenotyped neuropathy cohort
Journal article
BASKOZOS G. et al, (2024), Pain