BSc(Hons), MBBCh, PhD, FCP (SA), MRCP (UK)
Clinical Research Fellow
My research is focused on understanding the mechanisms of neuropathic pain. I use a combination of techniques, such as threshold tracking, intraepidermal nerve fibre density assessment and quantitative sensory testing, to assess the functional and structural integrity of the peripheral nervous system. These techniques allow me to explore peripheral neuronal processing in patients suffering from peripheral neuropathy. Most of my current research is focused on characterising the somatosensory, histological and electrophysiological phenotype of patients with diabetic neuropathic pain.
Rare NaV1.7 variants associated with painful diabetic peripheral neuropathy.
Blesneac I. et al, (2018), Pain, 159, 469 - 480
Immune or Genetic-Mediated Disruption of CASPR2 Causes Pain Hypersensitivity Due to Enhanced Primary Afferent Excitability.
Dawes JM. et al, (2018), Neuron, 97, 806 - 822.e10
A brain-based pain facilitation mechanism contributes to painful diabetic polyneuropathy.
Segerdahl AR. et al, (2018), Brain, 141, 357 - 364
Reply: Non-freezing cold injury: a multi-faceted syndrome.
Vale TA. et al, (2018), Brain, 141
Chronic non-freezing cold injury results in neuropathic pain due to a sensory neuropathy.
Vale TA. et al, (2017), Brain, 140, 2557 - 2569