Andreas Themistocleous

BSc(Hons), MBBCh, PhD, FCP (SA), MRCP (UK)

Clinical Lecturer in Neurophysiology

Research Summary

My research is focused on understanding the mechanisms of neuropathic pain. I use a combination of techniques, such as threshold tracking, intraepidermal nerve fibre density assessment and quantitative sensory testing, to assess the functional and structural integrity of the peripheral nervous system. These techniques allow me to explore peripheral neuronal processing in patients suffering from peripheral neuropathy. Most of my current research is focused on characterising the somatosensory, histological and electrophysiological phenotype of patients with diabetic neuropathic pain.

Key publications

Chronic non-freezing cold injury results in neuropathic pain due to a sensory neuropathy
Journal article

Vale TA. et al, (2017), Brain, 140, 2557 - 2569
Rare Nav1.7 variants associated with painful diabetic peripheral neuropathy
Journal article

Blesneac I. et al, (2017), PAIN, 1 - 1
The Pain in Neuropathy Study (PiNS)
Journal article

Themistocleous AC. et al, (2016), PAIN, 157, 1132 - 1145
A brain-based pain facilitation mechanism contributes to painful diabetic polyneuropathy
Journal article

Segerdahl AR. et al, (2018), Brain, 141, 357 - 364
Immune or Genetic-Mediated Disruption of CASPR2 Causes Pain Hypersensitivity Due to Enhanced Primary Afferent Excitability
Journal article

Dawes JM. et al, (2018), Neuron, 97, 806 - 822.e10

Recent publications

Whole-genome sequencing of a sporadic primary immunodeficiency cohort
Journal article

Thaventhiran JED. et al, (2020), Nature
Cold aggravates abnormal excitability of motor axons in oxaliplatin-treated patients.
Journal article

Bennedsgaard K. et al, (2020), Muscle Nerve
Germline selection shapes human mitochondrial DNA diversity.
Journal article

Wei W. et al, (2019), Science (New York, N.Y.), 364
Blocking tactile input to one finger using anaesthetic enhances touch perception and learning in other fingers.
Journal article

Dempsey-Jones H. et al, (2019), J Exp Psychol Gen, 148, 713 - 727
Defining the Functional Role of NaV1.7 in Human Nociception.
Journal article

McDermott LA. et al, (2019), Neuron, 101, 905 - 919.e8

More publications