BSc(Hons), MBBCh, PhD, FCP (SA), MRCP (UK)
Clinical Research Fellow
My research is focused on understanding the mechanisms of neuropathic pain. I use a combination of techniques, such as threshold tracking, intraepidermal nerve fibre density assessment and quantitative sensory testing, to assess the functional and structural integrity of the peripheral nervous system. These techniques allow me to explore peripheral neuronal processing in patients suffering from peripheral neuropathy. Most of my current research is focused on characterising the somatosensory, histological and electrophysiological phenotype of patients with diabetic neuropathic pain.
The novel activity of carbamazepine as an activation modulator extends from NaV1.7 mutations to the NaV1.8-S242T mutant channel from a patient with painful diabetic neuropathy.
Han C. et al, (2018), Mol Pharmacol
DOLORisk: study protocol for a multi-centre observational study to understand the risk factors and determinants of neuropathic pain
Pascal M. et al, (2018), Wellcome Open Research
Neuropathic pain drives anxiety behavior in mice, results consistent with anxiety levels in diabetic neuropathy patients.
Sieberg CB. et al, (2018), Pain Rep, 3
Rare NaV1.7 variants associated with painful diabetic peripheral neuropathy.
Blesneac I. et al, (2018), Pain, 159, 469 - 480
Immune or Genetic-Mediated Disruption of CASPR2 Causes Pain Hypersensitivity Due to Enhanced Primary Afferent Excitability.
Dawes JM. et al, (2018), Neuron, 97, 806 - 822.e10