Georgios Baskozos
MSc, PhD
Associate Professor
Bio-informatician
My main research interest lies in the bioinformatics of neuropathic pain including genetics, transcriptomics, functional genomics and predictive modelling. I have a particular interest in the transcriptional analysis of peripheral nerve injury both in humans and animal models of pain and I have developed a customised computational pipeline for the identification of novel long non-coding RNAs and gene model reconstruction using RNA-sequencing.
In addition, I have extensive experience in designing and implementing computational workflows for the analysis of Whole Genome and Exome Sequencing data working closely with experimental biologists and medical doctors.
I have also a keen interest in data analysis of large scale clinical datasets with heterogenous variables using exploratory data analysis, statistical learning and predictive modelling techniques. I am currently applying machine learning methods and developing computational workflows as the only directly appointed researcher for the Diabetes UK Project Grant 19/0005984 “Using machine learning to predict painful diabetic neuropathy”. I am also funded as a researcher co-investigator at the "Partnership for Assessment and Investigation of Neuropathic Pain: Studies Tracking Outcomes, Risks and Mechanisms (PAINSTORM)" UKRI - Versus Arthritis APDP grant.
Finally, I support my colleagues, being part of David Bennett’s group, with statistics, hypothesis testing and advice on experimental design.
Key publications
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Epidemiology of neuropathic pain: an analysis of prevalence and associated factors in UK Biobank
Journal article
Baskozos G. et al, (2023), PAIN Reports, 8, e1066 - e1066
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Classification of painful or painless diabetic peripheral neuropathy and identification of the most powerful predictors using machine learning models in large cross-sectional cohorts
Journal article
Baskozos G. et al, (2022), BMC Medical Informatics and Decision Making, 22
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The local molecular signature of human peripheral neuropathic pain
Journal article
Sandy-Hindmarch OP. et al, (2024), Pain
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Comprehensive analysis of long noncoding RNA expression in dorsal root ganglion reveals cell-type specificity and dysregulation after nerve injury
Journal article
Baskozos G. et al, (2019), Pain, 160, 463 - 485
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SLC45A4 is a pain gene encoding a neuronal polyamine transporter
Journal article
Middleton SJ. et al, (2025), Nature
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Deep RNA-seq of male and female murine sensory neuron subtypes after nerve injury
Journal article
Barry AM. et al, (2023), Pain, 164, 2196 - 2215
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Predicting ‘pain genes’: multi-modal data integration using probabilistic classifiers and interaction networks
Journal article
Zhao N. et al, (2024), Bioinformatics Advances, 4
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Investigating genotype-phenotype relationship of extreme neuropathic pain disorders in a national cohort: ’NIHR Bioresources Rare Disease – Neuropathic Pain Disorders’
Journal article
THEMISTOCLEOUS A. et al, (2022), Brain Communications
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Molecular and cellular correlates of human nerve regeneration: ADCYAP1/PACAP enhance nerve outgrowth
Journal article
Baskozos G. et al, (2020), Brain, 143, 2009 - 2026
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The effectiveness of Non-pharmaceutical interventions in reducing the COVID-19 contagion in the UK, an observational and modelling study
Journal article
Galanis G. et al, (2021), PLOS ONE, 16, e0260364 - e0260364
Recent publications
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SLC45A4 is a pain gene encoding a neuronal polyamine transporter
Journal article
Middleton SJ. et al, (2025), Nature
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NKG2D receptor ligands are cell surface biomarkers for injured murine and human nociceptive sensory neurons
Preprint
Wang S. et al, (2025)
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MEAanalysis: An Open-Source R package for Downstream Visualisation of AxIS Navigator Multi-Electrode Array Burst Data at the Single-Electrode Level
Journal article
Gordon EA. et al, (2025), Bioinformatics Advances
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Plasma periaxin is a biomarker of peripheral nerve demyelination
Journal article
Bellanti R. et al, (2025), Brain
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Serum Neurofilament Light Chain and Structural and Functional Nerve Fiber Loss in Painful and Painless Diabetic Polyneuropathy.
Journal article
Määttä LL. et al, (2025), Diabetes Res Clin Pract, 223
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Correction: Development and external validation of multivariable risk models to predict incident and resolved neuropathic pain: a DOLORisk Dundee study.
Journal article
Hébert HL. et al, (2024), J Neurol, 271, 7652 - 7653
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The local molecular signature of human peripheral neuropathic pain
Journal article
Sandy-Hindmarch OP. et al, (2024), Pain
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Prevalence of weakness and factors mediating discrepancy between reported and observed leg weakness in people with sciatica
Journal article
Dove L. et al, (2024), European Spine Journal, 33, 4229 - 4234
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Mechanisms of neurodynamic treatments (MONET): a protocol for a mechanistic, randomised, single-blind controlled trial in patients with carpal tunnel syndrome
Journal article
E. S-S. et al, (2024), BMC Musculoskeletal Disorders, 25
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What is associated with painful polyneuropathy? A cross-sectional analysis of symptoms and signs in patients with painful and painless polyneuropathy.
Journal article
Gierthmühlen J. et al, (2024), Pain
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Predicting “pain genes”: multi-modal data integration using probabilistic classifiers and interaction networks
Preprint
Zhao N. et al, (2024)
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Reliability of a clinical sensory test battery in patients with spine‐related leg and arm pain
Journal article
Bender C. et al, (2024), European Journal of Pain
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Predicting ‘pain genes’: multi-modal data integration using probabilistic classifiers and interaction networks
Journal article
Zhao N. et al, (2024), Bioinformatics Advances, 4
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The Molecular Signature of Neuropathic Pain in a Human Model System
Preprint
Sandy-Hindmarch OP. et al, (2024)
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GENOME-WIDE ASSOCIATION STUDY OF DIABETIC NEUROPATHY IN UK BIOBANK
Conference paper
Morsy H. et al, (2024), JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM, 29, S60 - S61
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THE ASSOCIATION BETWEEN DETAILED OBESITY MEASUREMENTS AND PERIPHERAL NEUROPATHY IN PERSONS WITH DIABETES
Conference paper
Reynolds E. et al, (2024), JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM, 29, S62 - S62
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Introduction to a special issue on big data and pain
Journal article
BASKOZOS G., (2023), PAIN Reports
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Deep RNA-seq of male and female murine sensory neuron subtypes after nerve injury
Journal article
Barry AM. et al, (2023), Pain, 164, 2196 - 2215
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Utilising clinical parameters to improve the selection of nerve biopsy candidates
Journal article
Kopanidis P. et al, (2023), Internal Medicine Journal
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Factors predicting the transition from acute to persistent pain in people with ‘sciatica’: the FORECAST longitudinal prognostic factor cohort study protocol
Journal article
Schmid AB. et al, (2023), BMJ Open, 13, e072832 - e072832
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Epidemiology of neuropathic pain: an analysis of prevalence and associated factors in UK Biobank
Journal article
Baskozos G. et al, (2023), PAIN Reports, 8, e1066 - e1066
-
Investigating genotype-phenotype relationship of extreme neuropathic pain disorders in a UK national cohort
Journal article
Themistocleous AC. et al, (2023), Brain Communications
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Types and Concentrations of Blood-Based Biomarkers in Adults With Peripheral Neuropathies
Journal article
Fundaun J. et al, (2022), JAMA Network Open, 5, e2248593 - e2248593
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Classification of painful or painless diabetic peripheral neuropathy and identification of the most powerful predictors using machine learning models in large cross-sectional cohorts
Journal article
Baskozos G. et al, (2022), BMC Medical Informatics and Decision Making, 22
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Deep RNA-seq of male and female murine sensory neuron subtypes after nerve injury
Preprint
Barry AM. et al, (2022)
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Cutaneous expression of growth-associated protein 43 is not a compelling marker for human nerve regeneration in carpal tunnel syndrome
Journal article
Carroll L. et al, (2022), PLOS ONE, 17, e0277133 - e0277133
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Development and external validation of multivariable risk models to predict incident and resolved neuropathic pain: a DOLORisk Dundee study
Journal article
Hebert H. et al, (2022), Journal of Neurology
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The power of integrating data: advancing pain research using meta-analysis
Journal article
Fundaun J. et al, (2022), PAIN Reports, 7, e1038 - e1038
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Investigating genotype-phenotype relationship of extreme neuropathic pain disorders in a national cohort: ’NIHR Bioresources Rare Disease – Neuropathic Pain Disorders’
Journal article
THEMISTOCLEOUS A. et al, (2022), Brain Communications
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Shared genetic susceptibility between trigger finger and carpal tunnel syndrome: a genome-wide association study
Journal article
Patel B. et al, (2022), The Lancet Rheumatology, 4, e556 - e565