After starting my undergrad studies in maths ("classes prépas" in Paris), and then moving to fundamental physics, I went on to specialise in Neuroscience, and also in Genetics, at Institut Pasteur, and later received my PhD from the University of Paris XI-Orsay in 2006, where I worked on structural and diffusion imaging of Huntington's disease. Since then, I have been working at the Oxford FMRIB Centre.

Being at the interface between basic neuroscience, methodological imaging development and clinical application is really what I enjoy the most. My body of work focuses on translational research from imaging methods to applied human neuroscience, such as brain maturation and ageing, and with an emphasis on neurodegenerative disorders (Alzheimer's disease, movement disorders, motor neuron disease).

My group has pursued two main lines of research, first by investigating the basal ganglia in health and movement disorders using high resolution MRI at 7T, and now by working on (very) large imaging datasets to identify - and make sense - of relevant clinical information (e.g., UK Biobank).

Useful Links

• My group: Translational Image Analysis Group
• My college: Green Templeton
• FSL (FMRIB Software Library)
• FSL-VBM: VBM protocol using FSL
• FLICA: FSL multi-modal linked ICA

SELECTED TEACHING AND VIDEO MATERIAL

• Wu Tsai Neuroscience Institute Seminar (Stanford 2023): Brain Imaging in UK Biobank
• Big Data in Biomedicine (Stanford 2015): Video of our talk discussing the results of our 2014 PNAS paper
• ISMRM Educational Talk (Melbourne 2012): Measuring Diffusion Properties in Tissue: The Diffusion Tensor & Derived Indices 
• ISMRM Educational Talk (Milan 2014): Functional connectivity: Diseases of connectivity

Selected scientific AND CLINICAL comments

• Nature News and Views discusses our SARS-CoV-2 Nature paper 2022
• Nature News and Views discusses our UK Biobank GWAS/imaging Nature paper 2018
• Jäncke, F1000 2019:
  Interesting Hypothesis - Very Good (Smith, 2019)
  
• Alzheimer Forum article on our work on vitamin B in MCI (2013)
• Alzheimer Forum article on our work on prediction of conversion to AD (2013)
• Masdeu, Curr Opin Neurol 2012:
  Paper of outstanding interest (Douaud, 2011)
  
• Draganski, Curr Opin Neurol 2010:
  Paper of outstanding interest (Douaud, 2009)
  
• Neurology Today article on our body of work in schizophrenia (2007-2009)

BIG DATA COLLABORATIONS

• UK Biobank Imaging Study
• Lifespan HCP
• Turing Institute

LATEST

Our latest study reveals the genetic and modifiable risk factors associated with the regions of the brain most vulnerable to ageing and disease:

Nature Communications 2024

If you have any additional questions, please contact me at: gwenaelle.douaud@ndcn.ox.ac.uk

Selected press coverage

• BBC 1 News segment on our SARS-CoV-2 paper in Nature
• NYT, BBC, Guardian (and Opinion by Eric Topol), CNN, amongst many others have also covered our SARS-CoV-2 study
  
• CNN, BBC, The Times, and Guardian coverage of our left-handedness paper in Brain
• RTÉ News segment (shortened video from my live TV interview with BBC World News) on our work on left-handedness
• Science News discusses the telling similarities between an elderly brain and a developing brain, featuring our 2014 PNAS paper
• BBC news article on our work on a link between development, ageing and diseases
• New Scientist article on our work on vitamin B in MCI

Research Summary

13. Deleterious effects in the brain are associated with mild SARS-CoV-2 infection 

Nature 2022 

12. Left-handedness is associated in the general population with gene variants related to the brain white matter cystoskeleton

Brain 2019

11. Very fine structure-function correspondence in the human brain, driven by both volume and cortical area information

J Neurosci 2019

10. Our PNAS paper on finding a common brain network linking development, ageing and vulnerability to disease is out

PNAS 2014

9. Effect of B vitamins/low homocysteine levels on grey matter atrophy in MCI; Bayesian modelling analysis demonstrating the causal pathway for the beneficial effect of treatment

PNAS 2013 + FAQs

8. Microstructural differences at baseline (SLF, fornix, hippocampus) between stable and progressing MCI; earliest abnormalities detected in MCI patients: 2.5 y before conversion to AD.

J Neurosci 2013

7. Novel approach to combine structural and functional connectivity information; increase of functional connectivity/decrease of structural connectivity in ALS reflects failure of cortical inhibitory function. 

Brain 2011

6. Diffusion differences between healthy ageing, MCI and Alzheimer's disease (AD) in crossing fibres (increased MO/FA); probabilistic tractography reveals relative sparing of motor pathways vs. association pathways.

NeuroImage 2011

5. Evidence for the corpus callosum involvement in amyotrophic lateral sclerosis (ALS) and its impact on grey matter atrophy. 

Neurology 2010

4. Common aetiological mechanisms for adolescent- and adult-onset schizophrenia with an altered neurodevelopmental time course in schizophrenia particularly salient in adolescence. 

Brain 2009

3. Analyses of FA, MD, PDD orientation and tractography to reveal in vivo the selective degeneration of the striato-pallidal projection pathways in HD. 

NeuroImage 2009

2. Anatomically-related grey and white matter abnormalities in language/auditory areas and, strikingly, in the primary sensorimotor system in early-onset schizophrenia. 

Brain 2007

1. In vivo dorso-ventral gradient of subcortical atrophy in Huntington's disease (HD); validation of automated VBM with manual ROI approach in HD. 

NeuroImage 2006

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