Jimena Perez Sanchez
Postdoctoral Research Scientist
I am interested the mechanisms by which the spinal cord can select somatosensory information that is relevant to navigate in the natural world, in normal and pathological conditions. My research focuses on the neural circuits that drive painful stimuli; from the activation of sensory neurons in the periphery, to descending pathways that modulate this information in the spinal cord. The spinal cord is an ideal system to study plastic changes that occur after injury because it is a relatively simple neural circuit, with direct input from sensory neurons and a measurable output. While a ‘taxonomic’ neurophysiological characterisation of different neuronal subpopulations may yield important insights, it also requires the understanding of how information is processed within these circuits.
I use electrophysiology, but also imaging and behavioural assays, to study the impact of changes in sensory afferents and dorsal horn neurons in the spinal cord. I believe that the combination of two-photon microscopy with electrophysiology can give powerful insight into the mechanisms of spinal cord plasticity in normal and pathological conditions.
Inhibition of sensory neuron driven acute, inflammatory, and neuropathic pain using a humanised chemogenetic system
Sanchez JP. et al, (2023)
Composite Fibrin and Carbon Microfibre Implant to Modulate Postraumatic Inflammation after Spinal Cord Injury
Escarrat V. et al, (2023), Cells, 12, 839 - 839
Sodium-calcium exchanger-3 regulates pain “wind-up”: From human psychophysics to spinal mechanisms
Trendafilova T. et al, (2022), Neuron, 110, 2571 - 2587.e13
Harnessing bacterial toxins to treat pain
Perez-Sanchez J. and Bennett DL., (2022), Nature Neuroscience, 25, 132 - 134
The structure of sensory afferent compartments in health and disease
Middleton SJ. et al, (2021), Journal of Anatomy